N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide

Base Information

Chemical Name:N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide
CAS No.:90253-96-6
Molecular Formula:C₁₃H₁₇NO₄
Molecular Weight:251.282
Hs Code.:
DSSTox Substance ID:DTXSID40533382

Synonyms:90253-96-6;N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide;DTXSID40533382

Suppliers and Price of N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:251.11575802
Heavy Atom Count:18
Complexity:305

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)C1=CC(=C(C=C1)OC)OC)NC(=O)C

Technology Process of N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide

There total 3 articles about N-[1-(3,4-Dimethoxyphenyl)-1-oxopropan-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 90253-98-8
2-Amino-1-(3,4-dimethoxyphenyl)-1-propanon-hydrochlorid

: 108-24-7
acetic anhydride

: 90253-96-6
2-(Acetylamino)-1-(3,4-dimethoxyphenyl)-1-propanon

Guidance literature:: With pyridine; for 15h;

Reference yield:

: 860746-60-7
N-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethyl]-acetamide

: 90253-96-6
2-(Acetylamino)-1-(3,4-dimethoxyphenyl)-1-propanon

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; for 2h;
DOI:10.1016/S0040-4039(02)01839-7

Reference yield:

: 29128-53-8
2-amino-1-(3,4-dimethoxyphenyl)propan-1-ol

: 90253-96-6
2-(Acetylamino)-1-(3,4-dimethoxyphenyl)-1-propanon

Guidance literature:: Multi-step reaction with 2 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide HCl / acetonitrile; H₂O / 18 h / 20 °C

2: SO₃*pyridine; Et₃N / dimethylsulfoxide / 2 h

With pyridine-SO₃ complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(02)01839-7