4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride

Base Information

Chemical Name:4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride
CAS No.:110642-79-0
Molecular Formula:C₂₇H₃₂N₄O₃*2ClH
Molecular Weight:533.498
Hs Code.:
DSSTox Substance ID:DTXSID50149352

Synonyms:110642-79-0;4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride;C27H32N4O3.2ClH;SCHEMBL10682329;DTXSID50149352;C27-H32-N4-O3.2Cl-H;LS-115605

Suppliers and Price of 4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride

Chemical Property:

Vapor Pressure:8.08E-18mmHg at 25°C
Boiling Point:650.7°Cat760mmHg
Flash Point:347.3°C
Density:g/cm³
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:532.2007963
Heavy Atom Count:36
Complexity:618

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=N1)C)[N+](=O)[O-])NCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl

Technology Process of 4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride

There total 3 articles about 4-Piperidinemethanol, 1-(2-((2,6-dimethyl-3-nitro-4-pyridinyl)amino)ethyl)-alpha,alpha-diphenyl-, dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 115-46-8
C₁₈H₂₁NO

: 110629-58-8
4-<(2-chloroethyl)amino>-2,6-dimethyl-3-nitropyridine

: 110642-79-0
{1-[2-(2,6-Dimethyl-3-nitro-pyridin-4-ylamino)-ethyl]-piperidin-4-yl}-diphenyl-methanol; hydrochloride

Guidance literature:: With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide; for 2h; Heating;
DOI:10.1016/0223-5234(89)90003-2

Reference yield:

: 15513-48-1
4-chloro-2,6-dimethyl-3-nitropyridine

: 110642-79-0
{1-[2-(2,6-Dimethyl-3-nitro-pyridin-4-ylamino)-ethyl]-piperidin-4-yl}-diphenyl-methanol; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / triethylamine / propan-2-ol / 20 h / Heating

2: 98 percent / thionylchloride / CH₂Cl₂ / 2 h / Heating

3: 40 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/0223-5234(89)90003-2

Reference yield:

: 125742-39-4
4-<(2-hydroxyethyl)amino>-2,6-dimethyl-3-nitropyridine

: 110642-79-0
{1-[2-(2,6-Dimethyl-3-nitro-pyridin-4-ylamino)-ethyl]-piperidin-4-yl}-diphenyl-methanol; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / thionylchloride / CH₂Cl₂ / 2 h / Heating

2: 40 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(89)90003-2