BisfluoroModafinil

Base Information

• Chemical Name: BisfluoroModafinil
• CAS No.: 90280-13-0
• Molecular Formula: C15H13F2NO2S
• Molecular Weight: 309.337
• Mol file: 90280-13-0.mol

Synonyms:Acetamide,2-[[bis(4-fluorophenyl)methyl]sulfinyl];2-(bis(4-fluorophenyl)methylsulfinyl)acetamide;2-((bis(4-fluorophenyl)methane)sulfinyl)acetamide;

Chemical Property of BisfluoroModafinil

Chemical Property:

• Melting Point: 78-80 °C
• Boiling Point: 558.7±50.0 °C(Predicted)
• PKA: 14.82±0.40(Predicted)
• PSA: 80.36000
• Density: 1.397±0.06 g/cm3(Predicted)
• LogP: 4.30360

Purity/Quality:

99%, ^*data from raw suppliers

2-((Bis(4-fluorophenyl)methyl)sulfinyl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bisfluoromodafinil (also known as CRL-40,940, flmodafinil, and lauflumide) is the bisfluoro analog of modafinil. It is the newest and strongest nootropic. It helps to enhance the mental intelligence and the motivation level. It improves brain power to solve problems and protects it from any chemical or physical injury. It can be used to treat attention deficit disorders, sleep disorders, and mild depression.

Technology Process of BisfluoroModafinil

There total 7 articles about BisfluoroModafinil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(bis(4-fluorophenyl)methylthio)acetamide (90280-20-9) → 2-((bis(4-fluorophenyl)methane)sulfinyl)acetamide (90280-13-0)

Guidance literature:

With dihydrogen peroxide; acetic acid;

Reference yield:

4,4'-difluorobenzhydryl alcohol (365-24-2) → 2-((bis(4-fluorophenyl)methane)sulfinyl)acetamide (90280-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 20 °C

2: potassium carbonate / acetone / 4 h / Reflux

3: methanol; ammonium hydroxide; ammonium chloride / 72 h / 50 °C

4: dihydrogen peroxide; acetic acid / methanol; water / 24 h / 40 °C

With methanol; ammonium hydroxide; dihydrogen peroxide; potassium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; In methanol; water; acetone;

DOI:10.1021/ml1002025

Reference yield:

methyl [[bis-(4-fluorophenyl)methyl]thio]acetate (90212-82-1) → 2-((bis(4-fluorophenyl)methane)sulfinyl)acetamide (90280-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; ammonium hydroxide; ammonium chloride / 72 h / 50 °C

2: dihydrogen peroxide; acetic acid / methanol; water / 24 h / 40 °C

With methanol; ammonium hydroxide; dihydrogen peroxide; ammonium chloride; acetic acid; In methanol; water;

DOI:10.1021/ml1002025

upstream raw materials:

methyl [[bis-(4-fluorophenyl)methyl]thio]acetate

2-(bis(4-fluorophenyl)methylthio)acetamide

2-((bis(4-fluorophenyl)methyl)-thio)acetic acid

4,4'-difluorobenzhydryl alcohol

Refernces

• 1、 Cao, Jianjing,Prisinzano, Thomas E.,Okunola, Oluyomi M.,Kopajtic, Theresa,Shook, Matthew,Katz, Jonathan L.,Newman, Amy Hauck. "SARs at the monoamine transporters for a novel series of modafinil analogues". . p. 48 - 52. Retrieved 2011/04/22.