L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

Base Information

• Chemical Name: L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester
• CAS No.: 90297-14-6
• Molecular Formula: C46H57N7O10
• Molecular Weight: 867.999

Synonyms:

Chemical Property of L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

There total 7 articles about L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl ((S)-1-oxo-1-(((S)-3-oxo-1,4-diphenylbutan-2-yl)amino)-3-phenylpropan-2-yl)carbamate (16879-80-4) → (S)-2-{(S)-2-[({[({[(S)-1-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (90297-14-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 83 percent / 4 M hydrochloric acid / dioxane

2: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

3: 90 percent / 4 M hydrochloric acid / dioxane

4: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

5: 94 percent / 4 M hydrochloric acid / dioxane

6: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;

DOI:10.1246/bcsj.57.90

Reference yield:

dicyclohexylammonium N-(tert-butoxycarbonyl)-L-phenylalaninate (4192-12-5) → (S)-2-{(S)-2-[({[({[(S)-1-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (90297-14-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

2: 83 percent / 4 M hydrochloric acid / dioxane

3: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

4: 90 percent / 4 M hydrochloric acid / dioxane

5: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

6: 94 percent / 4 M hydrochloric acid / dioxane

7: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;

DOI:10.1246/bcsj.57.90

Reference yield:

(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid benzyl ester (70669-41-9) → (S)-2-{(S)-2-[({[({[(S)-1-((S)-1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (90297-14-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / 4 M hydrochloric acid / dioxane

2: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

3: 94 percent / 4 M hydrochloric acid / dioxane

4: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;

DOI:10.1246/bcsj.57.90

upstream raw materials:

N-tert-butoxycarbonyl-L-prolyl-L-proline

tert-butyl ((S)-1-oxo-1-(((S)-3-oxo-1,4-diphenylbutan-2-yl)amino)-3-phenylpropan-2-yl)carbamate

dicyclohexylammonium N-(tert-butoxycarbonyl)-L-phenylalaninate

(S)-2-[(S)-2-(2-tert-Butoxycarbonylamino-acetylamino)-3-phenyl-propionylamino]-3-phenyl-propionic acid benzyl ester

Downstream raw materials:

C₅₇H₆₉N₁₃O₁₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 90297-14-6 L-Phenylalanine, N-[N-[N-[N-[N-[1-[1-[(1,1-dimethylethoxy)carbonyl]-L-prolyl]-L-prolyl]glycyl ]glycyl]glycyl]-L-phenylalanyl]-, phenylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send