Glycine, N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prolyl]-L -phenylalanyl]-L-prolyl]-L-prolyl]-, phenylmethyl ester

Base Information

Chemical Name:Glycine, N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prolyl]-L -phenylalanyl]-L-prolyl]-L-prolyl]-, phenylmethyl ester
CAS No.:90315-39-2
Molecular Formula:C55H65N7O11
Molecular Weight:1000.16
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prolyl]-L -phenylalanyl]-L-prolyl]-L-prolyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prolyl]-L -phenylalanyl]-L-prolyl]-L-prolyl]-, phenylmethyl ester

There total 13 articles about Glycine, N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prolyl]-L -phenylalanyl]-L-prolyl]-L-prolyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 90315-39-2
[((S)-1-{(S)-1-[(S)-2-({(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NMM, DCC / acetonitrile, 0 deg C, overnight

2: 60 percent / H₂ / Pd black / methanol

3: 1) NMM, ECF, 2) NMM

4: 98 percent / 4 M hydrogen chloride / dioxane / 1 h / Ambient temperature

5: DCC, NMM, HOBt / THF, 0 deg C, overnight

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol;
DOI:10.1246/bcsj.57.97

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 90315-39-2
[((S)-1-{(S)-1-[(S)-2-({(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NMM, DCC / acetonitrile, 0 deg C, overnight

2: 60 percent / H₂ / Pd black / methanol

3: 1) NMM, ECF, 2) NMM

4: 98 percent / 4 M hydrogen chloride / dioxane / 1 h / Ambient temperature

5: DCC, NMM, HOBt / THF, 0 deg C, overnight

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol;
DOI:10.1246/bcsj.57.97

Reference yield:

: 18532-06-4
Z-L-Pro-L-Phe-OEt

: 90315-39-2
[((S)-1-{(S)-1-[(S)-2-({(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / H₂, 0.3 M hydrogen chloride / Pd black / methanol

2: NMM, HOBt, DCC / THF, 0 deg C, overnight

3: 70 percent / 2 m NaOH / methanol

4: DCC, NMM, HOBt / THF, 0 deg C, overnight

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In methanol;
DOI:10.1246/bcsj.57.97