L-Isoleucine, N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prol yl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-, phenylmethyl ester

Base Information

• Chemical Name: L-Isoleucine, N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prol yl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-, phenylmethyl ester
• CAS No.: 90315-58-5
• Molecular Formula: C61H76N8O12
• Molecular Weight: 1113.32
• Mol file: 90315-58-5.mol

Synonyms:

Chemical Property of L-Isoleucine, N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prol yl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Isoleucine, N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prol yl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-, phenylmethyl ester

There total 13 articles about L-Isoleucine, N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]-L-prol yl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride (16652-71-4) → C61H76N8O12 (90315-58-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NMM, DCC / acetonitrile, 0 deg C, overnight

2: 60 percent / H₂ / Pd black / methanol

3: 1) NMM, ECF, 2) NMM

4: 83 percent / 4 M hydrogen chloride / dioxane

5: DCC, NMM, HOBt

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol;

DOI:10.1246/bcsj.57.97

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C61H76N8O12 (90315-58-5)

Guidance literature:

Multi-step reaction with 5 steps

1: NMM, DCC / acetonitrile, 0 deg C, overnight

2: 60 percent / H₂ / Pd black / methanol

3: 1) NMM, ECF, 2) NMM

4: 83 percent / 4 M hydrogen chloride / dioxane

5: DCC, NMM, HOBt

With 4-methyl-morpholine; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol;

DOI:10.1246/bcsj.57.97

Reference yield:

Z-L-Pro-L-Phe-OEt (18532-06-4) → C61H76N8O12 (90315-58-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / H₂, 0.3 M hydrogen chloride / Pd black / methanol

2: NMM, HOBt, DCC / THF, 0 deg C, overnight

3: 70 percent / 2 m NaOH / methanol

4: DCC, NMM, HOBt

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In methanol;

DOI:10.1246/bcsj.57.97

upstream raw materials:

(S)-2-({(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid

1-(tert-butoxycarbonyl)-L-proline

(S)-N-(benzyloxycarbonyl)valine

N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl ester