Chemical Property of Noladin ether
Chemical Property:
- Vapor Pressure:1.31E-11mmHg at 25°C
- Refractive Index:1.502
- Boiling Point:488.9 °C at 760 mmHg
- Flash Point:249.5 °C
- PSA：49.69000
- Density:0.948 g/cm3
- LogP:5.50190
- Storage Temp.:Desiccate at -20°C
- XLogP3:5.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:18
- Exact Mass:364.29774513
- Heavy Atom Count:26
- Complexity:379
- Purity/Quality:
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HU310 *data from reagent suppliers
Safty Information:
- Pictogram(s):
F
- Hazard Codes:F
- Statements:
11
- Safety Statements:
7-16
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCCCC=CCC=CCC=CCC=CCCCCOC(CO)CO
- Isomeric SMILES:CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CO)CO
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Description
2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay). It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively. 2-AG ether displays the typical tetrad of CB activities in mice. It is more chemically stable than 2-AG , with an endogenous half-life of hours rather than minutes. However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses. 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 μg per eye. It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork. Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.
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Uses
HU 310 is an endogenous GPR55 and CB1 receptors agonist. HU 310 has been shown to induce hyperglycia in rats. HU 310 can be used to investigate the biological roles of GPR55 and CB1 receptors.
