2,4-Dichloro-6-methoxyaniline

Base Information

• Chemical Name: 2,4-Dichloro-6-methoxyaniline
• CAS No.: 93839-14-6
• Molecular Formula: C7H7 Cl2 N O
• Molecular Weight: 192.045
• Hs Code.: 2922299090
• European Community (EC) Number: 298-783-9
• UNII: J64E6J8NJA
• DSSTox Substance ID: DTXSID90239726
• Nikkaji Number: J292.542G
• Wikidata: Q83122153
• Mol file: 93839-14-6.mol

Synonyms:2,4-Dichloro-6-methoxyaniline;93839-14-6;EINECS 298-783-9;J64E6J8NJA;2,4-Dichloro-6-methoxybenzenamine;UNII-J64E6J8NJA;SCHEMBL4401042;DTXSID90239726;MFCD20693704;Benzenamine, 2,4-dichloro-6-methoxy-;AS-59742;CS-0150462;C90753

Chemical Property of 2,4-Dichloro-6-methoxyaniline

Chemical Property:

• Vapor Pressure: 0.00559mmHg at 25°C
• Boiling Point: 273.9°Cat760mmHg
• PKA: 1.96±0.10(Predicted)
• Flash Point: 119.4°C
• PSA: 35.25000
• Density: 1.375g/cm³
• LogP: 3.16540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 190.9904692
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dichloro-6-methoxyaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC(=C1)Cl)Cl)N

Technology Process of 2,4-Dichloro-6-methoxyaniline

There total 8 articles about 2,4-Dichloro-6-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

3,5-dichloro-2-nitroanisole (74672-01-8) → 2,4-dichloro-6-methoxyaniline (93839-14-6)

Guidance literature:

With sodium dithionite; In ethanol; for 2h; Heating;

DOI:10.1021/tx990030j

Reference yield:

3,5-dichlorophenol (591-35-5) → 2,4-dichloro-6-methoxyaniline (93839-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂; H₂SO₄ / H₂O / 2 h / Heating

2: K₂CO₃ / dimethylformamide / 1 h / 60 °C

3: Sn / HCl / 1 h / Heating

With tin; sulfuric acid; potassium carbonate; sodium nitrite; In hydrogenchloride; water; N,N-dimethyl-formamide; 1: Nitration / 2: Methylation / 3: Reduction;

DOI:10.1002/(SICI)1099-1344(199911)42:11<1075::AID-JLCR263>3.0.CO;2-A

Reference yield:

3,5-dichloro-2-nitrophenol (74672-02-9) → 2,4-dichloro-6-methoxyaniline (93839-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 1 h / 60 °C

2: Sn / HCl / 1 h / Heating

With tin; potassium carbonate; In hydrogenchloride; N,N-dimethyl-formamide; 1: Methylation / 2: Reduction;

DOI:10.1002/(SICI)1099-1344(199911)42:11<1075::AID-JLCR263>3.0.CO;2-A

upstream raw materials:

3,5-dichloro-2-nitroanisole

2-methoxy-phenylamine

3,5-dichloro-4-nitroanisole

3,5-dichloroanisole

Downstream raw materials:

N-(2,6-dichloro-4-methoxyphenyl)acetamide

2-Chloro-1-(2,4-dichloro-6-methoxy-phenyl)-1H-pyrrole

2,3-Dichloro-1-(2,4-dichloro-6-methoxy-phenyl)-1H-pyrrole

1-(2,4-Dichloro-6-methoxy-phenyl)-1H-pyrrole-2-carboxylic acid