Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride

Base Information

• Chemical Name: Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride
• CAS No.: 122777-82-6
• Molecular Formula: C₁₂H₁₉N₃O₂S*ClH
• Molecular Weight: 305.829
• DSSTox Substance ID: DTXSID40153706
• Mol file: 122777-82-6.mol

Synonyms:N-(2-(Acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)acetamide hydrochloride;Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride;122777-82-6;C12H19N3O2S.ClH;DTXSID40153706;C12-H19-N3-O2-S.Cl-H;LS-7956

Chemical Property of Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride

Chemical Property:

• Vapor Pressure: 6.45E-09mmHg at 25°C
• Boiling Point: 467.6°Cat760mmHg
• Flash Point: 236.6°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 305.0964758
• Heavy Atom Count: 19
• Complexity: 310

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=CS1)N(CCN(C)C)C(=O)C.Cl

Technology Process of Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride

There total 2 articles about Acetamide, N-(2-(acetylamino)-3-thienyl)-N-(2-(dimethylamino)ethyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

acetic anhydride (108-24-7) + N-(2-Dimethylamino-ethyl)-N-(2-nitro-thiophen-3-yl)-acetamide; hydrochloride (122777-78-0) → N-(2-Acetylamino-thiophen-3-yl)-N-(2-dimethylamino-ethyl)-acetamide; hydrochloride (122777-82-6)

Guidance literature:

With iron; In acetic acid; for 3h; Heating;

DOI:10.1016/0223-5234(88)90099-2

Reference yield:

N,N-Dimethyl-N'-(2-nitro-thiophen-3-yl)-ethane-1,2-diamine; hydrochloride (122777-86-0) → N-(2-Acetylamino-thiophen-3-yl)-N-(2-dimethylamino-ethyl)-acetamide; hydrochloride (122777-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / acetic acid / 3 h / Heating

2: 60 percent / iron powder / acetic acid / 3 h / Heating

With iron; In acetic acid;

DOI:10.1016/0223-5234(88)90099-2

upstream raw materials:

acetic anhydride

N-(2-Dimethylamino-ethyl)-N-(2-nitro-thiophen-3-yl)-acetamide; hydrochloride

N,N-Dimethyl-N'-(2-nitro-thiophen-3-yl)-ethane-1,2-diamine; hydrochloride