N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine

Base Information

Chemical Name:N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine
CAS No.:125173-75-3
Molecular Formula:C29H33 Cl2 N3
Molecular Weight:494.4984
Hs Code.:
Mol file:125173-75-3.mol

Synonyms:9-(4-(N,N-Bis(2-chloroethyl))aminophenyl)hexylaminoacridine;9-Acridinamine,N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl];N-(6-(4-(Bis(2-chloroethyl)amino)phenyl)hexyl)-9-acridinamine;

Suppliers and Price of N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine

Chemical Property:

Vapor Pressure:1.67E-18mmHg at 25°C
Boiling Point:682.9°Cat760mmHg
Flash Point:366.8°C
PSA：31.39000
Density:1.213g/cm³
LogP:7.30890

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine

There total 7 articles about N-[6-[4-[bis(2-chloroethyl)amino]phenyl]hexyl]acridin-9-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125173-87-7
methyl 7-(4-nitrophenyl)heptanoate

: 125173-75-3
Acridin-9-yl-(6-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexyl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / methanol

2: 86 percent / AcOH / tetrahydrofuran / 48 h / 80 - 90 °C

3: POCl₃ / benzene / 1 h / Heating

4: conc. HCl / 0.67 h / Heating

5: Et₃N / acetone / 0.25 h / 0 °C

6: 1.) NaN₃, 2.) 8 M HCl / 1.) Me₂CO, H₂O, 0 deg C, 30 min, 2.) reflux, 10 min

7: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jm00166a015

Reference yield:

: 125173-88-8
7-(4-Amino-phenyl)-heptanoic acid methyl ester

: 125173-75-3
Acridin-9-yl-(6-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexyl)-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / AcOH / tetrahydrofuran / 48 h / 80 - 90 °C

2: POCl₃ / benzene / 1 h / Heating

3: conc. HCl / 0.67 h / Heating

4: Et₃N / acetone / 0.25 h / 0 °C

5: 1.) NaN₃, 2.) 8 M HCl / 1.) Me₂CO, H₂O, 0 deg C, 30 min, 2.) reflux, 10 min

6: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; acetic acid; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jm00166a015

Reference yield:

: 125173-90-2
7-<4-phenyl>heptanoic acid

: 125173-75-3
Acridin-9-yl-(6-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-hexyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / acetone / 0.25 h / 0 °C

2: 1.) NaN₃, 2.) 8 M HCl / 1.) Me₂CO, H₂O, 0 deg C, 30 min, 2.) reflux, 10 min

3: methanol / 24 h / 20 °C

With hydrogenchloride; sodium azide; triethylamine; In methanol; acetone;
DOI:10.1021/jm00166a015