Carbonic acid, 2-(4-methoxyphenyl)-4-(1-methylethyl)-5-oxazolyl methyl ester

Base Information

• Chemical Name: Carbonic acid, 2-(4-methoxyphenyl)-4-(1-methylethyl)-5-oxazolyl methyl ester
• CAS No.: 909122-68-5
• Molecular Formula: C15H17NO5
• Molecular Weight: 291.304
• Mol file: 909122-68-5.mol

Synonyms:

Chemical Property of Carbonic acid, 2-(4-methoxyphenyl)-4-(1-methylethyl)-5-oxazolyl methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid, 2-(4-methoxyphenyl)-4-(1-methylethyl)-5-oxazolyl methyl ester

There total 1 articles about Carbonic acid, 2-(4-methoxyphenyl)-4-(1-methylethyl)-5-oxazolyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(4-methoxyphenyl)-5-oxo-4-iso-propyl-4,5-dihydrooxazole (79137-48-7) + methyl chloroformate (79-22-1) → 2-(4-methoxyphenyl)-4-iso-propyloxazol-5-yl methyl carbonate (909122-68-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 25 ℃;

DOI:10.1021/ol061380h

Reference yield: 67.0%

2-(4-methoxyphenyl)-4-iso-propyloxazol-5-yl methyl carbonate (909122-68-5) → 4-isopropyl-5-oxo-2-(4-methoxyphenyl)-4,5-dihydrooxazole-4-carboxylic acid methyl ester

Guidance literature:

With 2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; potassium hexamethylsilazane; In tetrahydrofuran; at 20 - 25 ℃; for 0.0833333h;

DOI:10.1021/ol061380h

Reference yield:

2-(4-methoxyphenyl)-4-iso-propyloxazol-5-yl methyl carbonate (909122-68-5) → (R)-2-(4-Methoxy-phenyl)-4-methyl-5-oxo-4,5-dihydro-oxazole-4-carboxylic acid isopropyl ester + (S)-2-(4-Methoxy-phenyl)-4-methyl-5-oxo-4,5-dihydro-oxazole-4-carboxylic acid isopropyl ester

Guidance literature:

With (-)-1,2,3,4,5-pentamethyl-4-(pyrrolidino)pyridinoferrocene; In tert-Amyl alcohol; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja982890c

upstream raw materials:

2-(4-methoxyphenyl)-5-oxo-4-iso-propyl-4,5-dihydrooxazole

methyl chloroformate

Refernces

• 1、 Thomson, Jennifer E.,Campbell, Craig D.,Concellon, Carmen,Duguet, Nicolas,Rix, Kathryn,Slawin, Alexandra M. Z.,Smith, Andrew D.. "Probing the efficiency of N-heterocyclic carbene promoted O- to C-carboxyl transfer of oxazolyl carbonates". . p. 2784 - 2791. Retrieved 2008/09/20.