Acetic acid, [4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester

Base Information

Chemical Name:Acetic acid, [4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester
CAS No.:909124-84-1
Molecular Formula:C38H26BrClF7NO7S
Molecular Weight:889.039
Hs Code.:

Acetic acid,
[4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon
yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester

Synonyms:

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Chemical Property of Acetic acid, [4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Acetic acid, [4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester

There total 17 articles about Acetic acid, [4-[[1-[4-benzoyl-2-(3-bromopropoxy)phenyl]ethyl][(4-chlorophenyl)sulfon yl]amino]-2,5-difluorophenoxy]-, pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 920012-38-0
{4-[{1-[4-benzoyl-2-(3-bromo-propoxy)-phenyl]-ethyl}-(4-chloro-benzenesulfonyl)-amino]-2,5-difluoro-phenoxy}-acetic acid

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 909124-84-1
{4-[{1-[4-benzoyl-2-(3-bromo-propoxy)-phenyl]-ethyl}-(4-chloro-benzenesulfonyl)-amino]-2,5-difluoro-phenoxy}-acetic acid pentafluorophenyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 120103-18-6
2.5-difluoro-4-nitrophenol

: 909124-84-1
{4-[{1-[4-benzoyl-2-(3-bromo-propoxy)-phenyl]-ethyl}-(4-chloro-benzenesulfonyl)-amino]-2,5-difluoro-phenoxy}-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / K₂CO₃ / dimethylformamide / 20 °C

2: H₂ / Pd/C / methanol / 20 °C

3: 86 percent / pyridine / CH₂Cl₂ / 20 °C

4: TFA / CH₂Cl₂ / 0 - 20 °C

5: 85 percent / EDCI*HCl; HOBt*H₂O; Et₃N / dimethylformamide; tetrahydrofuran / 20 °C

6: 81 percent / PPh₃; DEAD / toluene / 0 - 20 °C

7: Pd(PPh₃)4; pyrrolidine / tetrahydrofuran / 20 °C

8: 54 percent / EDCI*HCl / CH₂Cl₂ / 20 °C

With pyrrolidine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 909124-64-7
3-hydroxy-4-iodo-N-methoxy-N-methyl-benzamide

: 909124-84-1
{4-[{1-[4-benzoyl-2-(3-bromo-propoxy)-phenyl]-ethyl}-(4-chloro-benzenesulfonyl)-amino]-2,5-difluoro-phenoxy}-acetic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

2: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

3: 70 percent / formic acid / 60 °C

4: 97 percent / NaBH₄ / methanol / 0 °C

5: 98 percent / tetrahydrofuran / -78 - 20 °C

6: 81 percent / PPh₃; DEAD / toluene / 0 - 20 °C

7: Pd(PPh₃)4; pyrrolidine / tetrahydrofuran / 20 °C

8: 54 percent / EDCI*HCl / CH₂Cl₂ / 20 °C

With pyrrolidine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Sonogashira coupling / 2: Mitsunobu reaction / 6: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091