Technology Process of 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid,
3-[[4-(4-morpholinylmethyl)benzoyl]amino]-, 2-methyl-2-phenylhydrazide
There total 10 articles about 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid,
3-[[4-(4-morpholinylmethyl)benzoyl]amino]-, 2-methyl-2-phenylhydrazide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 180 ℃;
for 0.05h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine
2.1: isopentyl nitrite / N,N-dimethyl-formamide / 2.5 h / 60 - 70 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / -5 - 25 °C
4.1: hydrazine / ethanol / 4 h / Heating / reflux
4.2: 4 h / 25 °C
5.1: trimethylaluminum / toluene / 1 h / 25 °C
5.2: 16 h / Heating / reflux
6.1: triethylamine / dichloromethane / 0.25 h / 25 °C
6.2: 4 h / 0 - 25 °C
7.1: potassium carbonate / tetrahydrofuran / 2 h / 25 °C
8.1: potassium carbonate / methanol / 0.05 h / 180 °C / Microwave irradiation
With
trimethylaluminum; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; isopentyl nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: isopentyl nitrite / N,N-dimethyl-formamide / 2.5 h / 60 - 70 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / -5 - 25 °C
3.1: hydrazine / ethanol / 4 h / Heating / reflux
3.2: 4 h / 25 °C
4.1: trimethylaluminum / toluene / 1 h / 25 °C
4.2: 16 h / Heating / reflux
5.1: triethylamine / dichloromethane / 0.25 h / 25 °C
5.2: 4 h / 0 - 25 °C
6.1: potassium carbonate / tetrahydrofuran / 2 h / 25 °C
7.1: potassium carbonate / methanol / 0.05 h / 180 °C / Microwave irradiation
With
trimethylaluminum; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; isopentyl nitrite;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
![tert-butyl 5-(N'-methyl-N'-phenylhydrazinocarbonyl)-3-(4-morpholin-4-ylmethylbenzoylamino)thieno[2,3-c]pyrazole-1-carboxylate](/Databaselist/images/loading.webp)
