Technology Process of 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid,
3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-,
2-(4-chlorophenyl)-2-methylhydrazide
There total 7 articles about 1H-Thieno[2,3-c]pyrazole-5-carboxylic acid,
3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-,
2-(4-chlorophenyl)-2-methylhydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 50 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl / tert-Amyl alcohol / 25 - 100 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -10 °C
2.2: 4 h / -10 - 25 °C
3.1: hydrogenchloride; water / tetrahydrofuran / 16 h / 50 °C
4.1: trimethylaluminum / toluene / 0.5 h / 0 - 25 °C
4.2: 2.5 h / 50 °C
4.3: 1 h / 25 °C
5.1: hydrogenchloride / tetrahydrofuran; water / 50 °C
With
hydrogenchloride; sodium hydroxide; water; trimethylaluminum; potassium hexamethylsilazane;
palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl;
In
tetrahydrofuran; tert-Amyl alcohol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 110 °C
2.1: trimethylaluminum / toluene / 0.5 h / 0 - 25 °C
2.2: 2.5 h / 50 °C
2.3: 1 h / 25 °C
3.1: hydrogenchloride / tetrahydrofuran; water / 50 °C
With
hydrogenchloride; potassium phosphate; copper(l) iodide; trimethylaluminum; N,N`-dimethylethylenediamine;
In
tetrahydrofuran; 1,4-dioxane; water; toluene;
