3(2H)-Pyridazinone,6-[7-methoxy-2-(1-methylethyl)pyrazolo[1,5-a]pyridin-4-yl]-2-(phenylmethyl)-

Base Information

Chemical Name:3(2H)-Pyridazinone,6-[7-methoxy-2-(1-methylethyl)pyrazolo[1,5-a]pyridin-4-yl]-2-(phenylmethyl)-
CAS No.:909720-32-7
Molecular Formula:C22H22N4O2
Molecular Weight:374.442
Hs Code.:

Synonyms:

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Chemical Property of 3(2H)-Pyridazinone,6-[7-methoxy-2-(1-methylethyl)pyrazolo[1,5-a]pyridin-4-yl]-2-(phenylmethyl)-

Chemical Property:

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Technology Process of 3(2H)-Pyridazinone,6-[7-methoxy-2-(1-methylethyl)pyrazolo[1,5-a]pyridin-4-yl]-2-(phenylmethyl)-

There total 10 articles about 3(2H)-Pyridazinone,6-[7-methoxy-2-(1-methylethyl)pyrazolo[1,5-a]pyridin-4-yl]-2-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 909720-21-4
2,3-dibromo-6-methoxypyridine

: 909720-32-7
C₂₂H₂₂N₄O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisopropylamine / tetrahydrofuran / 70 °C

2.1: dichloromethane

3.1: potassium carbonate / N,N-dimethyl-formamide

4.1: n-butyllithium / tetrahydrofuran / -78 °C

4.2: -78 - 20 °C

5.1: silica gel

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / Reflux

7.1: acetic acid / Reflux

8.1: sodium hydride / tetrahydrofuran

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; silica gel; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Sonogashira coupling / 6.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.04.021

Reference yield:

: 1332861-58-1
C₁₃H₁₉BN₂O₃

: 909720-32-7
C₂₂H₂₂N₄O₂

Guidance literature:: Multi-step reaction with 4 steps

1: silica gel

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / Reflux

3: acetic acid / Reflux

4: sodium hydride / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silica gel; sodium hydride; sodium carbonate; acetic acid; In tetrahydrofuran; water; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.04.021

Reference yield:

: 909720-22-5
3-bromo-6-methoxy-2-(3-methyl-1-butynyl)pyridine

: 909720-32-7
C₂₂H₂₂N₄O₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane

2.1: potassium carbonate / N,N-dimethyl-formamide

3.1: n-butyllithium / tetrahydrofuran / -78 °C

3.2: -78 - 20 °C

4.1: silica gel

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / Reflux

6.1: acetic acid / Reflux

7.1: sodium hydride / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; silica gel; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.04.021