Technology Process of Benzoic acid, 2-amino-5-methoxy-4-methyl-
There total 10 articles about Benzoic acid, 2-amino-5-methoxy-4-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-methoxy-6-methyl-indoline-2,3-dione;
With
sodium hydroxide; dihydrogen peroxide;
In
water;
at 35 ℃;
for 1.5h;
With
sulfuric acid;
In
water;
pH=4;
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 0 - 80 °C
2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 16 h / Reflux
3: methanol; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C
4: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C
With
hydrogenchloride; methanol; thionyl chloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane;
2: |Buchwald-Hartwig Coupling;