Technology Process of 2-Propenoic acid, 3-(2-ethyl-4-formyl-6-methylphenyl)-
There total 4 articles about 2-Propenoic acid, 3-(2-ethyl-4-formyl-6-methylphenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(2-ethyl-4-formyl-6-methyl-phenyl)propenoic acid methyl ester;
With
sodium hydroxide;
In
methanol; water;
at 20 ℃;
for 1h;
With
hydrogenchloride;
In
water;
DOI:10.1021/jm4014373
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 2.67 h / 20 °C / Cooling with ice
2: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 5 h / 115 °C / Inert atmosphere
3: sodium hydroxide / methanol; water / 1 h / 20 °C
With
pyridine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; sodium hydroxide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4014373
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / water / 115 °C / Dean-Stark
1.2: 3 h / Reflux
2.1: pyridine / dichloromethane / 2.67 h / 20 °C / Cooling with ice
3.1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 5 h / 115 °C / Inert atmosphere
4.1: sodium hydroxide / methanol; water / 1 h / 20 °C
With
pyridine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; acetic acid; triethylamine; sodium hydroxide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4014373
