Butanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-[[(1R)-1-[3-(trifluoromethyl) phenyl]ethyl]amino]-, 1,1-dimethylethyl ester, (3R)-

Base Information

• Chemical Name: Butanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-[[(1R)-1-[3-(trifluoromethyl) phenyl]ethyl]amino]-, 1,1-dimethylethyl ester, (3R)-
• CAS No.: 911069-02-8
• Molecular Formula: C25H29F3N2O5
• Molecular Weight: 494.511
• Mol file: 911069-02-8.mol

Synonyms:

Chemical Property of Butanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-[[(1R)-1-[3-(trifluoromethyl) phenyl]ethyl]amino]-, 1,1-dimethylethyl ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-[[(1R)-1-[3-(trifluoromethyl) phenyl]ethyl]amino]-, 1,1-dimethylethyl ester, (3R)-

There total 2 articles about Butanoic acid, 4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-[[(1R)-1-[3-(trifluoromethyl) phenyl]ethyl]amino]-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-α-(m-(trifluoromethyl)phenyl)ethylamine (127852-30-6) + (2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid (71449-08-6) → N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-{[(R)-1-(trifluoromethyl)phenyl]ethyl}amide (911069-02-8)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmc.2006.12.031

Reference yield: 100.0%

→ N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-{[(R)-1-(trifluoromethyl)phenyl]ethyl}amide (911069-02-8)

Guidance literature:

Reference yield: 100.0%

N-[(benzyloxy)carbonyl]-D-aspartic acid β-tert-butyl ester α-{[(R)-1-(trifluoromethyl)phenyl]ethyl}amide (911069-02-8) → D-aspartic acid β-tert-butyl ester α-{[(R)-1-(trifluoromethyl)phenyl]ethyl}amide (911069-05-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/j.bmc.2006.12.031

upstream raw materials:

(R)-α-(m-(trifluoromethyl)phenyl)ethylamine

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

Downstream raw materials:

D-aspartic acid β-tert-butyl ester α-{[(R)-1-(trifluoromethyl)phenyl]ethyl}amide

3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-[1-(3-trifluoromethyl-phenyl)-ethyl]-succinamic acid

3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-[1-(3-trifluoromethyl-phenyl)-ethyl]-succinamic acid tert-butyl ester