(3-chloro-5-iodophenyl)methanol

Base Information

• Chemical Name: (3-chloro-5-iodophenyl)methanol
• CAS No.: 912343-40-9
• Molecular Formula: C7H6ClIO
• Molecular Weight: 268.482
• Hs Code.: 2906210000
• Mol file: 912343-40-9.mol

Synonyms:(3-chloro-5-iodophenyl)methanol;

Chemical Property of (3-chloro-5-iodophenyl)methanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.43690

Purity/Quality:

95% ^*data from raw suppliers

3-Chloro-5-iodobenzylalcohol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chloro-5-iodophenyl)methanol

There total 2 articles about (3-chloro-5-iodophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-chloro-5-iodobenzoic acid methyl ester (289039-85-6) → (3-chloro-5-iodo-phenyl)-methanol (912343-40-9)

Guidance literature:

3-chloro-5-iodobenzoic acid methyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃;

With water; Rochelle's salt; In tetrahydrofuran;

Reference yield:

→ (3-chloro-5-iodo-phenyl)-methanol (912343-40-9)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 70 ℃; for 2h; Inert atmosphere;

Reference yield: 97.0%

(3-chloro-5-iodo-phenyl)-methanol (912343-40-9) → 1-bromomethyl-3-chloro-5-iodo-benzene (912343-41-0)

Guidance literature:

With bromine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

(3-chloro-5-iodo-phenyl)-methanol; In dichloromethane; at 0 ℃; for 1h;

upstream raw materials:

3-chloro-5-iodobenzoic acid methyl ester

Downstream raw materials:

1-bromomethyl-3-chloro-5-iodo-benzene

Refernces

• 1、 -. "2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 60; 61. . Retrieved 2013/05/23.