3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine

Base Information

Chemical Name:3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine
CAS No.:912343-45-4
Molecular Formula:C17H15Cl2N3O
Molecular Weight:348.232
Hs Code.:
DSSTox Substance ID:DTXSID301152744

Synonyms:SCHEMBL3978157;AMKIGGVLXKTCDG-UHFFFAOYSA-N;DTXSID301152744;3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine;912343-45-4;3-[[1-[(3,5-Dichlorophenyl)methyl]-1H-imidazol-2-yl]methoxy]benzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:347.0592175
Heavy Atom Count:23
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)OCC2=NC=CN2CC3=CC(=CC(=C3)Cl)Cl)N

Technology Process of 3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine

There total 4 articles about 3-[1-(3,5-Dichloro-benzyl)-1H-imidazol-2-ylmethoxy]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 912342-70-2
2-chloromethyl-1-(3,5-dichlorobenzyl)-1H-imidazole hydrochloride

: 912343-45-4
3-[1-(3,5-dichlorobenzyl)-1H-imidazol-2-ylmethoxy]phenylamine

Guidance literature:: m-Hydroxyaniline; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h;

2-chloromethyl-1-(3,5-dichlorobenzyl)-1H-imidazole hydrochloride; In N,N-dimethyl-formamide; for 0.333333h;

With water; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1-(3,5-dichlorobenzyl)-1H-imidazole

: 912343-45-4
3-[1-(3,5-dichlorobenzyl)-1H-imidazol-2-ylmethoxy]phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / 24 h / 120 °C / Sealed tube

1.2: 2 h

2.1: thionyl chloride / chloroform / 4 h / Heating / reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 0.33 h

With thionyl chloride; sodium hydride; In chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 912342-69-9
[1-(3,5-dichlorobenzyl)-1H-imidazol-2-yl]-methanol

: 912343-45-4
3-[1-(3,5-dichlorobenzyl)-1H-imidazol-2-ylmethoxy]phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / chloroform / 4 h / Heating / reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 0.33 h

With thionyl chloride; sodium hydride; In chloroform; N,N-dimethyl-formamide;