3-(2-METHOXY-PHENYL) PYRROLIDINE HCL

Base Information

• Chemical Name: 3-(2-METHOXY-PHENYL) PYRROLIDINE HCL
• CAS No.: 91246-24-1
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2933990090
• Mol file: 91246-24-1.mol

Synonyms:3-(2-Methoxyphenyl)pyrrolidine HCl;

Chemical Property of 3-(2-METHOXY-PHENYL) PYRROLIDINE HCL

Chemical Property:

• Boiling Point: 275.3±33.0 °C(Predicted)
• PKA: 10.13±0.10(Predicted)
• PSA: 21.26000
• Density: 1.024±0.06 g/cm3(Predicted)
• LogP: 2.10090
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

3-(2-Methoxyphenyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-METHOXY-PHENYL) PYRROLIDINE HCL

There total 2 articles about 3-(2-METHOXY-PHENYL) PYRROLIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-(2-methoxyphenyl)pyrrolidine (352231-45-9) → 3-(2-Methoxyphenyl)pyrrolidine (91246-24-1)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In methanol; for 17h; under 3102.97 Torr;

Reference yield:

→ 3-(2-Methoxyphenyl)pyrrolidine (91246-24-1)

Guidance literature:

Reference yield: 24.0%

3-(2-Methoxyphenyl)pyrrolidine (91246-24-1) + ethyl 1-(2,6-dimethoxyphenyl)-6-hydroxy-2-(5-methylpyridin-3-yl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate → 1-(2,6-dimethoxyphenyl)-6-hydroxy-5-(3-(2-methoxyphenyl)pyrrolidine-1-carbonyl)-2-(5-methylpyridin-3-yl)pyrimidin-4(1H)-one

Guidance literature:

With trimethylaluminum; In toluene; at 110 ℃; for 3h;

upstream raw materials:

1-benzyl-3-(2-methoxyphenyl)pyrrolidine

Downstream raw materials:

1-[3-(2-methoxy-phenyl)-pyrrolidin-1-yl]-propan-1-one

1-(4-fluorophenyl)-3-[3-(2-methoxyphenyl)pyrrolidin-1-yl]propan-1-one

1-(1.4-Dioxaspiro[4.5]dec-8-ylmethyl)-3-(2-methoxyphenyl)pyrrolidine

(-)-5-[3-(2-methoxyphenyl)pyrrolidin-1-carbonyl]-1H-pyridin-2-one

Refernces