2-Chlorobenzohydrazide

Base Information

• Chemical Name: 2-Chlorobenzohydrazide
• CAS No.: 5814-05-1
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 29280090
• European Community (EC) Number: 227-380-2
• NSC Number: 522531
• UNII: 5T829N5VTX
• DSSTox Substance ID: DTXSID40206882
• Nikkaji Number: J150.060K
• Wikidata: Q27455731
• ChEMBL ID: CHEMBL3237995
• Mol file: 5814-05-1.mol

Synonyms:2-Chlorobenzhydrazide;2-Chlorobenzohydrazide;5814-05-1;2-Chlorobenzoic hydrazide;2-Chlorobenzoic acid hydrazide;Benzoic acid, 2-chloro-, hydrazide;(2-Chlorobenzoyl)hydrazine;o-Chlorobenzhydrazide;2-chlorobenzene-1-carbohydrazide;5T829N5VTX;CHEMBL3237995;NSC-522531;benzoylhydrazine, O-chloro;chlorobenzohydrazide;5G1;2ClPhCON2;2-Chlorobenzoylhydrazine;2-Chlorobenzohydrazide #;UNII-5T829N5VTX;SCHEMBL406614;2-Chloro-benzoic acid hydrazide;2-Chlorobenzoic acid, hydrazide;2-Chlorobenzoic hydrazide, 98%;DTXSID40206882;CS-B1329;STR05371;EINECS 227-380-2;BBL008395;BDBM50001682;MFCD00007597;NSC522531;STK026833;O-CHLOROBENZOIC ACID HYDRAZIDE;AKOS000263762;NSC 522531;SB85915;BB 0240638;C2116;FT-0635865;EN300-18164;A915302;AE-842/31980017;J-509011;Q27455731;Z57248585;F0722-8811

Chemical Property of 2-Chlorobenzohydrazide

Chemical Property:

• Appearance/Colour: White to slightly beige crystalline powder
• Vapor Pressure: 2.35E-05mmHg at 25°C
• Melting Point: 113-118 °C
• Refractive Index: 1.592
• Boiling Point: 345.4 °C at 760 mmHg
• Flash Point: 162.7 °C
• PSA: 55.12000
• Density: 1.323 g/cm³
• LogP: 2.03470
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.0246905
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98% ^*data from raw suppliers

2-Chlorobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN)Cl

Technology Process of 2-Chlorobenzohydrazide

There total 10 articles about 2-Chlorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl chlorobenzoate (610-96-8) → 2-chlorobenzoylhydrazide (5814-05-1)

Guidance literature:

With hydrazine hydrate; at 20 ℃; for 2.5h; Cooling with ice;

Reference yield: 90.0%

ortho-chlorobenzoic acid (118-91-2) → 2-chlorobenzoylhydrazide (5814-05-1)

Guidance literature:

With hydrazine; at 250 ℃; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.03.007

Reference yield: 88.0%

ethyl 2-chlorobenzoate (7335-25-3) → 2-chlorobenzoylhydrazide (5814-05-1)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Reflux;

DOI:10.1016/j.bmc.2015.06.051

upstream raw materials:

ethyl 2-chlorobenzoate

methyl chlorobenzoate

ortho-chlorobenzoic acid

C₁₂H₁₅ClN₂O₃

Downstream raw materials:

2-chloro-benzoic acid benzylidenehydrazide

(E)-2-chloro-N'-(2-hydroxybenzylidene)benzohydrazide

N-benzenesulfonyl-N'-(2-chloro-benzoyl)-hydrazine

2-Chloro-benzoic acid [3-hydroxy-5,5-dimethyl-cyclohex-2-en-(Z)-ylidene]-hydrazide

Refernces

• 1、 El-Adl, Khaled,El-Helby, Abdel-Ghany A.,Ayyad, Rezk R.,Mahdy, Hazem A.,Khalifa, Mohamed M.,Elnagar, Hamdy A.,Mehany, Ahmed B.M.,Metwaly, Ahmed M.,Elhendawy, Mostafa A.,Radwan, Mohamed M.,ElSohly, Mahmoud A.,Eissa, Ibrahim H.. "Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors". . . Retrieved 2020/11/24.
• 2、 Abulkhair, Hamada S.,Eissa, Ibrahim H.,El-Adl, Khaled,ElSohly, Mahmoud A.,Elhendawy, Mostafa A.,Mehany, Ahmed. B. M.,Metwaly, Ahmed M.,Radwan, Mohamed M.,Sakr, Helmy M.,Yousef, Reda G.. "New quinoxaline-2(1H)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations". . p. 16949 - 16964. Retrieved 2021/09/27.