2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE

Base Information

• Chemical Name: 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE
• CAS No.: 145100-50-1
• Molecular Formula: C7H4F6N2O4S2
• Molecular Weight: 358.242
• Hs Code.: 29350090
• Mol file: 145100-50-1.mol

Synonyms:2-[N,N-Bis(trifluoromethanesulfonyl)amino]pyridine;2-[N,N-Bis(trifluoromethylsulfonyl)amino]pyridine;N-(2-Pyridyl)triflimide;

Chemical Property of 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE

Chemical Property:

• Appearance/Colour: White to almost white crystals or powder
• Vapor Pressure: 0.00024mmHg at 25°C
• Melting Point: 40-42 °C(lit.)
• Refractive Index: 1.485
• Boiling Point: 324.8 °C at 760 mmHg
• PKA: -5.98±0.10(Predicted)
• Flash Point: 150.2 °C
• PSA: 101.17000
• Density: 1.832 g/cm³
• LogP: 3.74880
• Storage Temp.: Refrigerator (+4°C)
• Sensitive.: Moisture Sensitive
• Water Solubility.: Hydrolyzes in water.

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Pyridyl)bis(trifluoromethanesulfonimide) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(2-Pyridyl)bis(trifluoromethanesulfonimide) is an intermediate used in the synthesis of aryl triflates and vinyl triflates.

Technology Process of 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE

There total 2 articles about 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-aminopyridine (504-29-0) + trifluoromethylsulfonic anhydride (358-23-6) → 1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide (145100-50-1)

Guidance literature:

With pyridine; In dichloromethane; 1.) -78 deg C, 1 h 2.) rt, 12 h;

DOI:10.1016/S0040-4039(00)60957-7

Reference yield:

→ 1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide (145100-50-1)

Guidance literature:

Reference yield: 95.5%

bis(3,5-bis(trifluoromethyl)phenyl)(2-hydroxy-1-phenoxathiinyl)phosphine oxide + 1,1,1-trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methane sulfonamide (145100-50-1) → bis(3,5-bis(trifluoromethyl)phenyl)(2-triflyloxy-1-phenoxathiinyl)phosphine oxide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 11h; Inert atmosphere;

DOI:10.1246/cl.180555

upstream raw materials:

2-aminopyridine

trifluoromethylsulfonic anhydride

Downstream raw materials:

Trifluoro-methanesulfonic acid (3S,4aR)-1-oxo-3-phenyl-4,4a,5,8-tetrahydro-3H-pyrido[1,2-c][1,3]oxazin-6-yl ester

Trifluoro-methanesulfonic acid (1R,4S)-2-(4-methoxy-benzyl)-3-oxo-2-aza-bicyclo[2.2.1]hept-5-en-6-yl ester

(2S,3S,6R)-6-(4-Benzyloxy-butyl)-2-(3-chloro-propyl)-3-methyl-4-trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Trifluoro-methanesulfonic acid (R)-4-[(S)-2-(2-isobutyl-[1,3]dioxolan-2-yl)-1-methyl-ethyl]-cyclohex-1-enyl ester