(6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride

Base Information

• Chemical Name: (6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride
• CAS No.: 915069-47-5
• Molecular Formula: C₁₀H₈ClN₃*ClH
• Molecular Weight: 242.108
• Mol file: 915069-47-5.mol

Synonyms:

Chemical Property of (6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride

Chemical Property:

• PSA: 37.81000
• LogP: 3.74860

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride

There total 1 articles about (6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4,6-dichloropyrimidine (1193-21-1) + aniline (62-53-3) → (6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride (915069-47-5)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 2.5h; Heating;

DOI:10.1016/j.tet.2006.08.065

Reference yield:

(6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride (915069-47-5) → N,6-diphenyl-3,4,6,7-tetrahydro-2H-pyrimido[1,6-c]quinazolin-2-imine

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Reflux; Inert atmosphere

2: hydrogenchloride / water; ethanol / 20 °C

3: sodium tetrahydroborate / methanol / 53 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; potassium carbonate; In 1,4-dioxane; methanol; ethanol; water; 1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2016.04.036

Reference yield:

(6-chloro-pyrimidin-4-yl)-phenyl-amine hydrochloride (915069-47-5) → 6-(2-(benzylideneamino)phenyl)-N-phenylpyrimidin-4-amine

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / Reflux; Inert atmosphere

2: hydrogenchloride / water; ethanol / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; ethanol; water; 1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tet.2016.04.036

upstream raw materials:

4,6-dichloropyrimidine

aniline

Refernces

• 1、 -. "SUBSTITUTED PYRIDINES AND PYRIMIDINES". Page/Page column 18. . Retrieved 2012/12/13.
• 2、 Hartung, Christian G.,Backes, Alexander C.,Felber, Beatrice,Missio, Andrea,Philipp, Alexander. "Efficient microwave-assisted synthesis of highly functionalized pyrimidine derivatives". . p. 10055 - 10064. Retrieved 2007/10/03.