Technology Process of 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol
There total 10 articles about 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethylsulfide; boron trifluoride diethyl etherate;
at 0 - 5 ℃;
for 0.166667h;
DOI:10.1021/jm100659v
- Guidance literature:
-
With
formic acid; ammonium formate;
5%-palladium/activated carbon;
In
methanol;
at 20 ℃;
for 19h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C
2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere
3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere
4: dimethylsulfide; boron trifluoride diethyl etherate / 0.17 h / 0 - 5 °C
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; dimethylsulfide; boron trifluoride diethyl etherate; tetrabutylammomium bromide; oxygen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; sodium t-butanolate;
In
1,4-dioxane; water; toluene; tetramethylurea;
2: Buchwald-Hartwig amination / 3: Suzuki coupling;
DOI:10.1021/jm100659v
