3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol

Base Information

Chemical Name:3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol
CAS No.:915410-98-9
Molecular Formula:C19H15N3O
Molecular Weight:301.348
Hs Code.:
ChEMBL ID:CHEMBL1649617
DSSTox Substance ID:DTXSID60575542
Nikkaji Number:J2.939.738D
Wikidata:Q82464905

Synonyms:915410-98-9;Phenol, 3-(1H-indol-4-yl)-5-(3-pyridinylamino)-;3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol;SCHEMBL3929221;CHEMBL1649617;DTXSID60575542

Suppliers and Price of 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:301.121512110
Heavy Atom Count:23
Complexity:391

Purity/Quality:: 99%+, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C2C=CNC2=C1)C3=CC(=CC(=C3)O)NC4=CN=CC=C4

Technology Process of 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol

There total 10 articles about 3-(1H-Indol-4-yl)-5-[(pyridin-3-yl)amino]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1260030-08-7
N-(3-(1H-indol-4-yl)-5-(4-methoxybenzyloxy)phenyl)pyridin-3-amine

: 915410-98-9
3-(1H-Indol-4-yl)-5-(pyridin-3-ylamino)phenol

Guidance literature:: With dimethylsulfide; boron trifluoride diethyl etherate; at 0 - 5 ℃; for 0.166667h;
DOI:10.1021/jm100659v

Reference yield: 35.0%

: [3-benzyloxy-5-(1H-indol-4-yl)-phenyl]-pyridin-3-yl-amine

: 915410-98-9
3-(1H-Indol-4-yl)-5-(pyridin-3-ylamino)phenol

Guidance literature:: With formic acid; ammonium formate; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 19h;

Reference yield:

: 6311-60-0
3,5-dibromonitrobenzene

: 915410-98-9
3-(1H-Indol-4-yl)-5-(pyridin-3-ylamino)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 24 h / 90 °C / Inert atmosphere

3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

4: dimethylsulfide; boron trifluoride diethyl etherate / 0.17 h / 0 - 5 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; dimethylsulfide; boron trifluoride diethyl etherate; tetrabutylammomium bromide; oxygen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; sodium t-butanolate; In 1,4-dioxane; water; toluene; tetramethylurea; 2: Buchwald-Hartwig amination / 3: Suzuki coupling;
DOI:10.1021/jm100659v