2(1H)-Pyridinone, 5-[[3-hydroxy-5-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]amino]-

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Chemical Name:2(1H)-Pyridinone, 5-[[3-hydroxy-5-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]amino]-
CAS No.:915411-55-1
Molecular Formula:C28H35N3O2Si
Molecular Weight:473.69
Hs Code.:

Synonyms:

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Chemical Property of 2(1H)-Pyridinone, 5-[[3-hydroxy-5-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]amino]-

Chemical Property:

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Technology Process of 2(1H)-Pyridinone, 5-[[3-hydroxy-5-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]amino]-

There total 7 articles about 2(1H)-Pyridinone, 5-[[3-hydroxy-5-[1-[tris(1-methylethyl)silyl]-1H-indol-4-yl]phenyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₃N₃O₃Si

: 915411-55-1
5-[3-hydroxy-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenylamino]-pyridin-2-ol

Guidance literature:: C₃₆H₄₃N₃O₃Si; With boron trifluoride diethyl etherate; methanol; In dimethylsulfide; at 0 ℃; for 0.333333h;

With sodium hydrogencarbonate; In dimethylsulfide; water; pH=7;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 915411-55-1
5-[3-hydroxy-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenylamino]-pyridin-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 16 h / 120 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 120 °C / Microwave irradiation

3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 2585.81 Torr

4.2: 0.17 h / Cooling with ice-NaCl

With potassium phosphate; hydrogen; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 2.1: Buchwald reaction / 3.1: Suzuki Coupling;

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915411-55-1
5-[3-hydroxy-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenylamino]-pyridin-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 1 h / 120 °C / Microwave irradiation

2.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 2585.81 Torr

3.2: 0.17 h / Cooling with ice-NaCl

With potassium phosphate; hydrogen; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 1.1: Buchwald reaction / 2.1: Suzuki Coupling;