3-Pyridinamine, N-[3-(1H-indol-4-yl)-5-methoxyphenyl]-

Base Information

Chemical Name:3-Pyridinamine, N-[3-(1H-indol-4-yl)-5-methoxyphenyl]-
CAS No.:915411-80-2
Molecular Formula:C20H17N3O
Molecular Weight:315.374
Hs Code.:

Synonyms:

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Chemical Property of 3-Pyridinamine, N-[3-(1H-indol-4-yl)-5-methoxyphenyl]-

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Technology Process of 3-Pyridinamine, N-[3-(1H-indol-4-yl)-5-methoxyphenyl]-

There total 6 articles about 3-Pyridinamine, N-[3-(1H-indol-4-yl)-5-methoxyphenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₇N₃OSi

: 915411-80-2
N-(3-(1H-indol-4-yl)-5-methoxyphenyl)pyridin-3-amine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm100659v

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 915411-80-2
N-(3-(1H-indol-4-yl)-5-methoxyphenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 90 °C / Inert atmosphere

2: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; water; toluene; 1: Buchwald-Hartwig amination / 2: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 6311-60-0
3,5-dibromonitrobenzene

: 915411-80-2
N-(3-(1H-indol-4-yl)-5-methoxyphenyl)pyridin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 90 °C / Inert atmosphere

3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; oxygen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; water; toluene; tetramethylurea; 2: Buchwald-Hartwig amination / 3: Suzuki coupling;
DOI:10.1021/jm100659v