LP-261

Base Information

Chemical Name:LP-261
CAS No.:915412-67-8
Molecular Formula:C₂₂H₁₉N₃O₄S
Molecular Weight:421.477
Hs Code.:
UNII:O547O19Z01
Wikidata:Q27285346
Mol file:915412-67-8.mol

Synonyms:LP 261;LP-261;LP261 cpd;N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide

Suppliers and Price of LP-261

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LP-261 95.00%
5MG
$ 495.77

Total 5 raw suppliers

Chemical Property of LP-261

Chemical Property:

PSA：109.53000
LogP:4.99480
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:421.10962727
Heavy Atom Count:30
Complexity:710

Purity/Quality:

97% ^*data from raw suppliers

LP-261 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=NC=CC(=C1)C(=O)C2=CC(=CC(=C2)C3=C4C=CNC4=CC=C3)NS(=O)(=O)C

Technology Process of LP-261

There total 7 articles about LP-261 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 915412-67-8
N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexane / -75 - -70 °C / Inert atmosphere

1.2: -75 - -71 °C / Inert atmosphere

1.3: -25 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3.1: sodium / 18 h / 80 °C

4.1: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutyl ammonium fluoride; sodium; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; water; 4.1: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 915412-58-7
(2-chloropyridin-4-yl)(3,5-dibromophenyl)methanone

: 915412-67-8
N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

2: sodium / 18 h / 80 °C

3: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutyl ammonium fluoride; sodium; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; 3: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 915412-66-7
N-[3-bromo-5-(2-chloropyridine-4-carbonyl)phenyl]methanesulfonamide

: 915412-67-8
N-[3-(1H-indol-4-yl)-5-(2-methoxypyridine-4-carbonyl)phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium / 18 h / 80 °C

2: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran

With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutyl ammonium fluoride; sodium; In tetrahydrofuran; 1,4-dioxane; water; 2: Suzuki coupling;
DOI:10.1021/jm100659v