5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[( 2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[( 2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-
CAS No.:917470-58-7
Molecular Formula:C37H43N3O7SSi
Molecular Weight:701.916
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[(
2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[( 2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[( 2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)-

There total 2 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[benzoyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]amino]methyl]-8-oxo-7-[( 2-phenylacetyl)amino]-, (4-methoxyphenyl)methyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 104146-10-3
(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 82475-72-7
O-(tert-butyldimethylsilyl)benzohydroxamic acid

: 917470-58-7
3-[(tert-butyldimethylsilyloxy)benzamido]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Guidance literature:: (6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester; With palladium diacetate; triphenylphosphine; at 0 ℃; Inert atmosphere;

O-(tert-butyldimethylsilyl)benzohydroxamic acid; With sodium hydride; at 0 ℃;
DOI:10.1021/acs.joc.6b02272

Reference yield: 29.3%

: 104146-10-3
(6R,7R)-3-Chloromethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 82475-72-7
O-(tert-butyldimethylsilyl)benzohydroxamic acid

: C₃₇H₄₃N₃O₇SSi

: 917470-58-7
3-[(tert-butyldimethylsilyloxy)benzamido]methyl-7-phenylacetamido-3-cephem-4-carboxylic acid p-methoxybenzyl ester

Guidance literature:: With sodium hydride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1039/b612475e