Butanoic acid, 4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy) carbonyl]amino]-, methyl ester, (3S)-

Base Information

Chemical Name:Butanoic acid, 4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy) carbonyl]amino]-, methyl ester, (3S)-
CAS No.:917610-66-3
Molecular Formula:C33H47N3O9Si
Molecular Weight:657.836
Hs Code.:

Butanoic acid,
4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1
-dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy)
carbonyl]amino]-, methyl ester, (3S)-

Synonyms:

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Chemical Property of Butanoic acid, 4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy) carbonyl]amino]-, methyl ester, (3S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy) carbonyl]amino]-, methyl ester, (3S)-

There total 2 articles about Butanoic acid, 4-[[2-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-4-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]phenyl]amino]-4-oxo-3-[[(phenylmethoxy) carbonyl]amino]-, methyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 917610-57-2
{2-[2-amino-5-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-methyl-2-oxo-ethyl}-carbamic acid tert-butyl ester

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 917610-66-3
3-benzyloxycarbonylamino-N-[2-(2-tert-butoxycarbonylamino-propionyl)-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-succinamic acid methyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In chloroform; at 20 ℃; for 12h;
DOI:10.1021/jo0614442

Reference yield:

: {1-[4-(tert-butyl-dimethyl-silanyloxy)-phenylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

: 917610-66-3
3-benzyloxycarbonylamino-N-[2-(2-tert-butoxycarbonylamino-propionyl)-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / acetonitrile / 24 h / 20 °C / Irradiation

2: 73 percent / DCC; DMAP / CHCl₃ / 12 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; In chloroform; acetonitrile; 1: photo-Fries rearrangement;
DOI:10.1021/jo0614442

Reference yield:

: 917610-66-3
3-benzyloxycarbonylamino-N-[2-(2-tert-butoxycarbonylamino-propionyl)-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-succinamic acid methyl ester

: [5-(1-benzoylamino-ethyl)-7-hydroxy-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / HCOONH₄ / Pd(OH)2/C / propan-2-ol / 0.1 h / 95 °C / microwave irradiation

2: TFA; Et₃SiH / CH₂Cl₂ / 2 h / 20 °C

3: pyridine / CHCl₃ / 12 h / 20 °C

With pyridine; triethylsilane; ammonium formate; trifluoroacetic acid; palladium dihydroxide; In dichloromethane; chloroform; isopropyl alcohol;
DOI:10.1021/jo0614442