1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-

Base Information

Chemical Name:1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-
CAS No.:107659-31-4
Molecular Formula:C19H19 N3 O4
Molecular Weight:353.3719
Hs Code.:
DSSTox Substance ID:DTXSID60910454
ChEMBL ID:CHEMBL10471
Mol file:107659-31-4.mol

Synonyms:107659-31-4;1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-;2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(1,2,4-triazol-4-yl)propan-1-one;CHEMBL10471;DTXSID60910454;2-Hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)propan-1-one

Suppliers and Price of 1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-

Chemical Property:

Vapor Pressure:2.25E-15mmHg at 25°C
Boiling Point:602.7°Cat760mmHg
Flash Point:318.3°C
Density:1.24g/cm³
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:353.13755610
Heavy Atom Count:26
Complexity:456

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)C(CN2C=NN=C2)(C3=CC=C(C=C3)OC)O

Technology Process of 1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)-

There total 2 articles about 1-Propanone, 2-hydroxy-1,2-bis(4-methoxyphenyl)-3-(4H-1,2,4-triazol-4-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288-88-0
1,2,4-Triazole

: (4-Methoxy-phenyl)-[2-(4-methoxy-phenyl)-oxiranyl]-methanone

: 94147-88-3
2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-3-[1,2,4]triazol-1-yl-propan-1-one

: 107659-31-4
2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-3-[1,2,4]triazol-4-yl-propan-1-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 0.333333h; Yield given. Yields of byproduct given;
DOI:10.1021/jm00389a016

Reference yield:

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 107659-31-4
2-Hydroxy-1,2-bis-(4-methoxy-phenyl)-3-[1,2,4]triazol-4-yl-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; dioxane / 16 h / Ambient temperature

2: NaH / dimethylformamide / 0.33 h / 50 °C

With sodium hydride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00389a016