1-Piperidinecarboxylic acid, 4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol- 4-yl]phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol- 4-yl]phenyl]-, 1,1-dimethylethyl ester
CAS No.:917899-37-7
Molecular Formula:C29H37ClN4O4S
Molecular Weight:573.156
Hs Code.:

1-Piperidinecarboxylic acid,
4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol-
4-yl]phenyl]-, 1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol- 4-yl]phenyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol- 4-yl]phenyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-(4-chlorophenyl)-4-[4-[1-[(dimethylamino)sulfonyl]-5-ethyl-1H-pyrazol- 4-yl]phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 917899-36-6
tert-butyl 4-(4-chlorophenyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate

: 4-Bromo-5-ethyl-N,N-dimethyl-1H-pyrazole-1-sulfonamide

: 917899-37-7
4-(4-chloro-phenyl)-4-[4-(1-dimethylsulphamoyl-5-ethyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene; at 80 ℃; for 17h;

Reference yield:

: 57988-58-6
4-(4-bromophenyl)-4-hydroxy-piperidine

: 917899-37-7
4-(4-chloro-phenyl)-4-[4-(1-dimethylsulphamoyl-5-ethyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / 3 h / 0 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2.5 h / 80 °C

4: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 17 h / 80 °C

With potassium phosphate; potassium acetate; triethylamine; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 857531-97-6
4-(4-bromophenyl)-4-(4-chlorophenyl)-piperidine hydrochloride

: 917899-37-7
4-(4-chloro-phenyl)-4-[4-(1-dimethylsulphamoyl-5-ethyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 72 h / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 2.5 h / 80 °C

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; ethanol; water; toluene / 17 h / 80 °C

With potassium phosphate; potassium acetate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; toluene;