Valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine

Base Information

• Chemical Name: Valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine
• CAS No.: 93245-71-7
• Molecular Formula: C₂₈H₄₀N₆O₁₀
• Molecular Weight: 620.66
• DSSTox Substance ID: DTXSID90239347
• Nikkaji Number: J533.471C
• Wikidata: Q83121689
• Mol file: 93245-71-7.mol

Synonyms:Val-Tyr-Pro-isoAsp-Gly-Ala;valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine

Chemical Property of Valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1114.5°Cat760mmHg
• Flash Point: 627.8°C
• Density: 1.367g/cm³
• XLogP3: -3.4
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 15
• Exact Mass: 620.28059149
• Heavy Atom Count: 44
• Complexity: 1080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N2CCCC2C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(C)C(=O)O)N
• Isomeric SMILES: C[C@@H](C(=O)O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](C(C)C)N

Technology Process of Valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine

There total 5 articles about Valyl-tyrosyl-prolyl-isoaspartyl-glycyl-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Val-L-Tyr-L-Pro-L-Asn-Gly-L-Ala (105760-58-5) → L-Val-L-Tyr-L-Pro-L-cyclic imide-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-Asp-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-isoAsp-Gly-L-Ala (93245-71-7)

Guidance literature:

With water; at 50 ℃; for 2880h; Further Variations:; Reagents; in polymer matrixes; Kinetics; Product distribution;

DOI:10.1021/js9802289

Reference yield:

L-Val-L-Tyr-L-Pro-L-Asn-Gly-L-Ala (105760-58-5) → (S)-2-{2-[(R)-3-({(S)-1-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-2,5-dioxo-pyrrolidin-1-yl]-acetylamino}-propionic acid + L-Val-L-Tyr-L-Pro-L-cyclic imide-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-Asp-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-isoAsp-Gly-L-Ala (93245-71-7)

Guidance literature:

With water; at 50 ℃; for 4383h; Further Variations:; Reagents; in polymer matrixes; Kinetics; Product distribution;

DOI:10.1021/js980227g

Reference yield:

L-Val-L-Tyr-L-Pro-L-Asn-Gly-L-Ala (105760-58-5) → L-Val-L-Tyr-L-Pro-L-cyclic imide-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-Asp-Gly-L-Ala + L-Val-L-Tyr-L-Pro-L-Asp + L-Val-L-Tyr-L-Pro-L-isoAsp-Gly-L-Ala (93245-71-7)

Guidance literature:

With poly(vinylpyrrolidone); sulfuric acid; at 70 ℃; pH=0.17; Further Variations:; Solvents; pH-values; Reagents; Kinetics; Product distribution;

DOI:10.1002/1520-6017(200102)90:2<141::AID-JPS5>3.0.CO;2-Y

upstream raw materials:

L-Val-L-Tyr-L-Pro-L-Asn-Gly-L-Ala

Refernces

• 1、 Song, Yuan,Schowen, Richard L.,Borchardt, Ronald T.,Topp, Elizabeth M.. "Effect of pH on the rate of asparagine deamidation in polymeric formulations: pH -rate profile". . p. 141 - 156. Retrieved 2001.
• 2、 Stratton, Lewis P.,Kelly, R. Michael,Rowe, Jared,Shively, Jesse E.,Smith, D. David,Carpenter, John F.,Manning, Mark C.. "Controlling deamidation rates in a model peptide: Effects of temperature, peptide concentration, and additives". . p. 2141 - 2148. Retrieved 2001.