6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one

Base Information

Chemical Name:6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one
CAS No.:918306-97-5
Molecular Formula:C16H9ClO4
Molecular Weight:300.69300
Hs Code.:
DSSTox Substance ID:DTXSID90583034
Nikkaji Number:J2.396.118K
Wikidata:Q82474543

Synonyms:918306-97-5;6-(5-Chloro-2-hydroxybenzoyl)-4H-chromen-4-one;6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one;DTXSID90583034

Suppliers and Price of 6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one

Chemical Property:

PSA：67.51000
LogP:3.38300
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:300.0189365
Heavy Atom Count:21
Complexity:461

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1C(=O)C3=C(C=CC(=C3)Cl)O)C(=O)C=CO2

Technology Process of 6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one

There total 2 articles about 6-(5-Chloro-2-hydroxybenzoyl)-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 122-51-0
orthoformic acid triethyl ester

: 220042-68-2
1-[5-(5-chloro-2-hydroxybenzoyl)-2-hydroxyphenyl]ethanone

: 918306-97-5
6-(5-chloro-2-hydroxybenzoyl)chromone

Guidance literature:: With perchloric acid; In water; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2006.09.029

Reference yield:

: 42248-31-7
6-Chloro-4-oxo-4H-chromene-3-carbaldehyde

: 918306-97-5
6-(5-chloro-2-hydroxybenzoyl)chromone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Me₃SiOTf / 0.17 h / 20 °C

1.2: 25 percent / CH₂Cl₂ / 12 h / 20 °C

2.1: 65 percent / perchloric acid / H₂O / 12 h / 20 °C

With perchloric acid; trimethylsilyl trifluoromethanesulfonate; In water; 1.2: Michael addition;
DOI:10.1016/j.tet.2006.09.029

Reference yield: 70.0%

: 918306-97-5
6-(5-chloro-2-hydroxybenzoyl)chromone

: 81114-98-9
Chan's diene

: 7-hydroxy-2-(5-chloro-2-hydroxybenzoyl)benzo[c]chromen-6-one

Guidance literature:: 6-(5-chloro-2-hydroxybenzoyl)chromone; With trimethylsilyl trifluoromethanesulfonate; at 20 ℃; for 1h;

Chan's diene; In dichloromethane; at 20 ℃; for 12h;

With triethylamine; In ethanol; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2006.09.029