2-Propenoic acid, 3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy- 1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy- 1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-
CAS No.:918308-84-6
Molecular Formula:C₃₅H₄₁N₅O₅S
Molecular Weight:643.807
Hs Code.:

2-Propenoic acid,
3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy-
1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-,
1,1-dimethylethyl ester, (2E)-

Synonyms:

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Chemical Property of 2-Propenoic acid, 3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy- 1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy- 1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

There total 4 articles about 2-Propenoic acid, 3-[8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carbonyl]-2-[4-[(4-hydroxy- 1-piperidinyl)methyl]phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881997-05-3
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918308-84-6
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-{4-[(4-hydroxypiperidin-1-yl)methyl]phenyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 815 mg / Na₂CO₃ / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane; H₂O / 23 h / Heating

2: 649 mg / CBr₄; Ph₃P / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

3: 184 mg / tetrahydrofuran / 64 h / 0 - 20 °C

With carbon tetrabromide; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki cross-coupling;
DOI:10.1016/j.bmc.2006.08.037

Reference yield:

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 918308-84-6
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-{4-[(4-hydroxypiperidin-1-yl)methyl]phenyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 815 mg / Na₂CO₃ / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane; H₂O / 23 h / Heating

2: 649 mg / CBr₄; Ph₃P / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

3: 184 mg / tetrahydrofuran / 64 h / 0 - 20 °C

With carbon tetrabromide; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki cross-coupling;
DOI:10.1016/j.bmc.2006.08.037

Reference yield:

: 918309-14-5
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[4-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918308-84-6
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-{4-[(4-hydroxypiperidin-1-yl)methyl]phenyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 649 mg / CBr₄; Ph₃P / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

2: 184 mg / tetrahydrofuran / 64 h / 0 - 20 °C

With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2006.08.037