Benzoic acid, 2,4,5-triamino-3-fluoro-, methyl ester

Base Information

• Chemical Name: Benzoic acid, 2,4,5-triamino-3-fluoro-, methyl ester
• CAS No.: 918321-27-4
• Molecular Formula: C8H10FN3O2
• Molecular Weight: 199.185
• Mol file: 918321-27-4.mol

Synonyms:

Chemical Property of Benzoic acid, 2,4,5-triamino-3-fluoro-, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2,4,5-triamino-3-fluoro-, methyl ester

There total 1 articles about Benzoic acid, 2,4,5-triamino-3-fluoro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2,4-diamino-3-fluoro-5-nitrobenzoate (918321-18-3) → methyl 2,4,5-triamino-3-fluorobenzoate (918321-27-4)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In tetrahydrofuran; methanol; at 50 ℃; for 6h; under 2625.26 Torr; Product distribution / selectivity;

Reference yield: 94.0%

methyl 2,4,5-triamino-3-fluorobenzoate (918321-27-4) + orthoformic acid triethyl ester (122-51-0) → 6-amino-7-fluoro-5H-benzoimidazole-5-carboxylic acid methyl ester (918321-29-6)

Guidance literature:

methyl 2,4,5-triamino-3-fluorobenzoate; orthoformic acid triethyl ester; With sulfuric acid; In tetrahydrofuran; at 60 ℃; for 6h;

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; pH=7.5;

Reference yield:

methyl 2,4,5-triamino-3-fluorobenzoate (918321-27-4) + formaldehyde diethyl acetal (462-95-3) → methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate (918321-20-7)

Guidance literature:

methyl 2,4,5-triamino-3-fluorobenzoate; formaldehyde diethyl acetal; With toluene-4-sulfonic acid; In water; acetonitrile; at 60 - 65 ℃; for 4h;

With pyridine; In water; acetonitrile; at 20 ℃; for 3.16667h;

upstream raw materials:

methyl 2,4-diamino-3-fluoro-5-nitrobenzoate

Downstream raw materials:

6-amino-7-fluoro-5H-benzoimidazole-5-carboxylic acid methyl ester

methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate

Refernces