Ethanol, 2-chloro-2-[(4-methylphenyl)sulfinyl]-, 1-acetate

Base Information

• Chemical Name: Ethanol, 2-chloro-2-[(4-methylphenyl)sulfinyl]-, 1-acetate
• CAS No.: 918404-05-4
• Molecular Formula: C11H13ClO3S
• Molecular Weight: 260.741
• Mol file: 918404-05-4.mol

Synonyms:

Chemical Property of Ethanol, 2-chloro-2-[(4-methylphenyl)sulfinyl]-, 1-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanol, 2-chloro-2-[(4-methylphenyl)sulfinyl]-, 1-acetate

There total 2 articles about Ethanol, 2-chloro-2-[(4-methylphenyl)sulfinyl]-, 1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxyethyl p-tolyl sulfoxide (87943-26-8) + acetic anhydride (108-24-7) → acetic acid 2-chloro-2-(toluene-4-sulfinyl)-ethyl ester (918404-05-4)

Guidance literature:

2-hydroxyethyl p-tolyl sulfoxide; acetic anhydride; With pyridine;

With N-chloro-succinimide; In tetrachloromethane;

DOI:10.1016/j.tetlet.2006.09.165

Reference yield:

di(p-tolyl) disulfide (103-19-5) → acetic acid 2-chloro-2-(toluene-4-sulfinyl)-ethyl ester (918404-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: PPh₃

1.2: mCPBA / CH₂Cl₂

2.1: pyridine

2.2: NCS / CCl₄

With pyridine; triphenylphosphine;

DOI:10.1016/j.tetlet.2006.09.165

Reference yield: 96.0%

acetic acid 2-chloro-2-(toluene-4-sulfinyl)-ethyl ester (918404-05-4) → 1-chlorovinyl p-tolyl sulfoxide (184705-48-4)

Guidance literature:

With lithium anion of δ-valerolactam; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.09.165

upstream raw materials:

2-hydroxyethyl p-tolyl sulfoxide

acetic anhydride

di(p-tolyl) disulfide

Downstream raw materials:

1-chlorovinyl p-tolyl sulfoxide

tert-butyl 4-chloro-2-(2-phenylethyl)-4-(p-tolylsulfinyl)butyrate

Refernces