Mitomycin K

Base Information

• Chemical Name: Mitomycin K
• CAS No.: 74148-45-1
• Molecular Formula: C16H18N2O4
• Molecular Weight: 302.33
• DSSTox Substance ID: DTXSID40995587
• Nikkaji Number: J551.550E
• ChEMBL ID: CHEMBL284124
• Mol file: 74148-45-1.mol

Synonyms:Mitomycin K;74148-45-1;Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-1,5-dimethyl-8-methylene-, (1aS-(1a-alpha,8a-alpha,8b-alpha))-;CHEMBL284124;DTXSID40995587;LS-23422;6,8a-Dimethoxy-1,5-dimethyl-8-methylidene-1,1a,2,8,8a,8b-hexahydroazireno[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione

Chemical Property of Mitomycin K

Chemical Property:

• Melting Point: 92-93 °C
• Boiling Point: 463.7°Cat760mmHg
• Flash Point: 234.3°C
• PSA: 58.85000
• Density: 1.37g/cm³
• LogP: 0.09920
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 302.12665706
• Heavy Atom Count: 22
• Complexity: 720

Purity/Quality:

MITOMYCIN K 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2=C)OC)N4C)OC
• Isomeric SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3(C2=C)OC)N4C)OC

Technology Process of Mitomycin K

There total 1 articles about Mitomycin K which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mitomycin B (4055-40-7) → (+)-mitomycin K (74148-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / tetrahydrofuran / 120 h / 5 °C

2: 79 percent / sodium hydride / benzene; dimethylformamide / 0.33 h / -15 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

Reference yield: 90.0%

(+)-mitomycin K (74148-45-1) → 10-Des(carbamoyloxy)-9-dehydroporfiromycin (74148-46-2)

Guidance literature:

With ammonium hydroxide; In methanol; for 4h; Ambient temperature;

upstream raw materials:

mitomycin B

Downstream raw materials:

10-Des(carbamoyloxy)-9-dehydroporfiromycin