Tienopramine

Base Information

Chemical Name:Tienopramine
CAS No.:37967-98-9
Molecular Formula:C17H20N2S
Molecular Weight:284.4191
Hs Code.:2934999090
UNII:36L0QUK8SY
DSSTox Substance ID:DTXSID80191400
Nikkaji Number:J19.678I
Wikipedia:Tienopramine
Wikidata:Q7801061
NCI Thesaurus Code:C75183
ChEMBL ID:CHEMBL2105442
Mol file:37967-98-9.mol

Synonyms:Tienopramine;37967-98-9;Tienopramine [INN];UNII-36L0QUK8SY;36L0QUK8SY;N,N-dimethyl-3-thieno[3,2-b][1]benzazepin-10-ylpropan-1-amine;CHEMBL2105442;DTXSID80191400;Q7801061;4-(3-(Dimethylamino)propyl)-4H-thieno(3,2-b)(1)benzazepine

Suppliers and Price of Tienopramine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TIENOPRAMINE 95.00%
5MG
$ 498.40

Total 5 raw suppliers

Chemical Property of Tienopramine

Chemical Property:

Vapor Pressure:3.17E-07mmHg at 25°C
Boiling Point:418.9°Cat760mmHg
Flash Point:207.1°C
PSA：34.72000
Density:1.128g/cm³
LogP:4.38670
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:284.13471982
Heavy Atom Count:20
Complexity:342

Purity/Quality:

99% ^*data from raw suppliers

TIENOPRAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCCN1C2=C(C=CC3=CC=CC=C31)SC=C2

Technology Process of Tienopramine

There total 10 articles about Tienopramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22751-23-1
(2-nitrophenyl)acetyl chloride

: 37967-98-9
(3-benzo[b]thieno[2,3-f]azepin-4-yl-propyl)-dimethyl-amine

Guidance literature:: Multi-step reaction with 9 steps

1: SnCl₄ / benzene / Ambient temperature

2: p-toluenesulfonic acid / 150 °C

3: 98 percent / Zn, CH₃COOH

4: DCC, / ethyl acetate

5: 1.) K₂CO₃, Cu, 2.) alkali / 1.) mesitylene, reflux, 22 h

6: 95 percent / HCl / ethanol

7: NaBH₄ / dioxane; H₂O / 50 °C

8: Al₂O₃ CBT 1 (PECHINEY) / benzene / Heating

9: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

With hydrogenchloride; sodium tetrahydroborate; Al₂O₃ CBT 1 (PECHINEY); tin(IV) chloride; copper; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; ethyl acetate; benzene;

Reference yield:

: 38078-81-8
2-[2-(3-Bromo-thiophen-2-yl)-[1,3]dioxolan-2-ylmethyl]-phenylamine

: 37967-98-9
(3-benzo[b]thieno[2,3-f]azepin-4-yl-propyl)-dimethyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: DCC, / ethyl acetate

2: 1.) K₂CO₃, Cu, 2.) alkali / 1.) mesitylene, reflux, 22 h

3: 95 percent / HCl / ethanol

4: NaBH₄ / dioxane; H₂O / 50 °C

5: Al₂O₃ CBT 1 (PECHINEY) / benzene / Heating

6: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

With hydrogenchloride; sodium tetrahydroborate; Al₂O₃ CBT 1 (PECHINEY); copper; sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; ethyl acetate; benzene;

Reference yield:

: 38078-79-4
1-(3-Bromo-thiophen-2-yl)-2-(2-nitro-phenyl)-ethanone

: 37967-98-9
(3-benzo[b]thieno[2,3-f]azepin-4-yl-propyl)-dimethyl-amine

Guidance literature:: Multi-step reaction with 8 steps

1: p-toluenesulfonic acid / 150 °C

2: 98 percent / Zn, CH₃COOH

3: DCC, / ethyl acetate

4: 1.) K₂CO₃, Cu, 2.) alkali / 1.) mesitylene, reflux, 22 h

5: 95 percent / HCl / ethanol

6: NaBH₄ / dioxane; H₂O / 50 °C

7: Al₂O₃ CBT 1 (PECHINEY) / benzene / Heating

8: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / Heating

With hydrogenchloride; sodium tetrahydroborate; Al₂O₃ CBT 1 (PECHINEY); copper; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; water; ethyl acetate; benzene;