2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(2-hydroxyethyl)-7-methoxy-6-(phenylmethoxy)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(2-hydroxyethyl)-7-methoxy-6-(phenylmethoxy)-, 1,1-dimethylethyl ester
CAS No.:918896-63-6
Molecular Formula:C24H31NO5
Molecular Weight:413.514
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(2-hydroxyethyl)-7-methoxy-6-(phenylmethoxy)-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(2-hydroxyethyl)-7-methoxy-6-(phenylmethoxy)-, 1,1-dimethylethyl ester

There total 12 articles about 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-(2-hydroxyethyl)-7-methoxy-6-(phenylmethoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 918896-62-5
6-benzyloxy-1-ethoxycarbonylmethyl-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 918896-63-6
6-benzyloxy-1-(2-hydroxy-ethyl)-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 0 - 20 ℃;
DOI:10.1016/j.tet.2006.09.056

Reference yield:

: 918896-59-0
1-benzyloxy-4-bromo-2-methoxy-5-(2-nitro ethyl)benzene

: 918896-63-6
6-benzyloxy-1-(2-hydroxy-ethyl)-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminum hydride / tetrahydrofuran / 20 °C

2: 1.90 g / tetrahydrofuran; H₂O / 4 h / 20 °C

3: 89 percent / triethylamine; poly(ethylene glycol) / palladium(II) acetate / 18 h / 80 °C

4: TFA / CH₂Cl₂ / 0 - 20 °C

5: sodium carbonate / CH₂Cl₂ / 12 h

6: 1.0 g / CH₂Cl₂ / 4 h

7: 87 percent / LiCl; sodium borohydride / ethanol; tetrahydrofuran / 0 - 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium carbonate; ethylene glycol; triethylamine; trifluoroacetic acid; lithium chloride; poly(ethylene glycol); palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; 3: Heck reaction / 5: Michael reaction;
DOI:10.1016/j.tet.2006.09.056

Reference yield:

: 918896-60-3
2-[2-bromo-4-methoxy-5-benzyloxy]-1-(tert-butoxycarbonyl amino)-ethane

: 918896-63-6
6-benzyloxy-1-(2-hydroxy-ethyl)-7-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / triethylamine; poly(ethylene glycol) / palladium(II) acetate / 18 h / 80 °C

2: TFA / CH₂Cl₂ / 0 - 20 °C

3: sodium carbonate / CH₂Cl₂ / 12 h

4: 1.0 g / CH₂Cl₂ / 4 h

5: 87 percent / LiCl; sodium borohydride / ethanol; tetrahydrofuran / 0 - 20 °C

With sodium tetrahydroborate; sodium carbonate; ethylene glycol; triethylamine; trifluoroacetic acid; lithium chloride; poly(ethylene glycol); palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; 1: Heck reaction / 3: Michael reaction;
DOI:10.1016/j.tet.2006.09.056