4-[(3-Chloropropyl)sulfonyl]morpholine

Base Information

• Chemical Name: 4-[(3-Chloropropyl)sulfonyl]morpholine
• CAS No.: 21297-82-5
• Molecular Formula: C7H14ClNO3S
• Molecular Weight: 227.712
• NSC Number: 140223
• DSSTox Substance ID: DTXSID30300964
• Wikidata: Q82044431
• Mol file: 21297-82-5.mol

Synonyms:4-[(3-chloropropyl)sulfonyl]morpholine;21297-82-5;4-(3-chloropropylsulfonyl)morpholine;NSC140223;SCHEMBL1667599;DTXSID30300964;WKNBIINFAYTUAG-UHFFFAOYSA-N;4-(3-chloropropyl-sulfonyl)morpholine;NSC-140223

Chemical Property of 4-[(3-Chloropropyl)sulfonyl]morpholine

Chemical Property:

• Vapor Pressure: 2.82E-05mmHg at 25°C
• Boiling Point: 357°Cat760mmHg
• Flash Point: 169.7°C
• Density: 1.33g/cm³
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 227.0382922
• Heavy Atom Count: 13
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1S(=O)(=O)CCCCl

Technology Process of 4-[(3-Chloropropyl)sulfonyl]morpholine

There total 1 articles about 4-[(3-Chloropropyl)sulfonyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 3-chloro-n-propanesulfonyl chloride (1633-82-5) → 4-(3-chloro-propane-1-sulfonyl)-morpholine (21297-82-5)

Guidance literature:

With triethylamine;

DOI:10.1021/jo01263a022

Reference yield:

4-(3-chloro-propane-1-sulfonyl)-morpholine (21297-82-5) + N6-cyclohexyl-N2-[2-methoxy-4-(4-piperidyl)phenyl]-9H-purine-2,6-diamine (1246533-10-7) → N6-cyclohexyl-N2-(2-methoxy-4-{1-[3-(morpholin-4-ylsulfonyl)propyl]piperidin-4-yl}phenyl)-9H-purine-2,6-diamine (1246531-86-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

4-(3-chloro-propane-1-sulfonyl)-morpholine (21297-82-5) + 5-{2-[(4-hydroxy-3-methoxyphenyl)amino]pyrimidin-4-yl}-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile (1292313-13-3) → 5-[2-({3-methoxy-4-[3-(morpholin-4-ylsulfonyl)propoxy]phenyl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile (1292310-72-5)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 - 100 ℃;

upstream raw materials:

morpholine

3-chloro-n-propanesulfonyl chloride

Downstream raw materials:

2-{[3-(Morpholin-4-ylsulfonyl)propyl]sulfanyl}-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

N₆-cyclohexyl-N₂-(2-methoxy-4-{1-[3-(morpholin-4-ylsulfonyl)propyl]piperidin-4-yl}phenyl)-9H-purine-2,6-diamine

5-[2-({3-methoxy-4-[3-(morpholin-4-ylsulfonyl)propoxy]phenyl}amino)pyrimidin-4-yl]-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile

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