Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Base Information

Chemical Name:Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS No.:76981-79-8
Molecular Formula:C₂₁H₂₃NO₃S
Molecular Weight:369.485
Hs Code.:

Synonyms:76981-79-8;BRN 5611336;ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate;Benzo(b)thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-6-methyl-2-((1-oxo-3-phenyl-2-propenyl)amino)-, ethyl ester;ETHYL 6-METHYL-2-[[(E)-3-PHENYLPROP-2-ENOYL]AMINO]-4,5,6,7-TETRAHYDROBENZOTHIOPHENE-3-CARBOXYLATE;AKOS002262731;AKOS016312473;ethyl 6-methyl-2-[[(E)-3-phenylprop-2-enoyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate;LS-41183;F0866-0528;ET 2-(CINNAMOYLAMINO)-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE

Suppliers and Price of Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Chemical Property:

Vapor Pressure:3.72E-14mmHg at 25°C
Boiling Point:595.7°Cat760mmHg
Flash Point:314.1°C
Density:1.223g/cm³
XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:369.13986477
Heavy Atom Count:26
Complexity:529

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC2=C1CCC(C2)C)NC(=O)C=CC3=CC=CC=C3
Isomeric SMILES:CCOC(=O)C1=C(SC2=C1CCC(C2)C)NC(=O)/C=C/C3=CC=CC=C3

Technology Process of Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

There total 3 articles about Ethyl 2-cinnamamido-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 76981-71-0
2-amino-6-methyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 76981-79-8
6-Methyl-2-[(E)-(3-phenyl-acryloyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Guidance literature:: With pyridine; for 1.5h; Heating;

Reference yield:

: 589-92-4
1-methylcyclohexan-4-one

: 76981-79-8
6-Methyl-2-[(E)-(3-phenyl-acryloyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / sulphur, diethylamine / ethanol / 1.5 h

2: 85 percent / pyridine / 1.5 h / Heating

With pyridine; sulfur; diethylamine; In ethanol;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 76981-79-8
6-Methyl-2-[(E)-(3-phenyl-acryloyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / sulphur, diethylamine / ethanol / 1.5 h

2: 85 percent / pyridine / 1.5 h / Heating

With pyridine; sulfur; diethylamine; In ethanol;