(5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Base Information

Chemical Name:(5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one
CAS No.:919081-43-9
Molecular Formula:C10H9F2NO3
Molecular Weight:229.183
Hs Code.:
DSSTox Substance ID:DTXSID10582382
Wikidata:Q82473794

Synonyms:919081-43-9;(5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one;DTXSID10582382

Suppliers and Price of (5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:229.05504947
Heavy Atom Count:16
Complexity:277

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(=O)N1C2=CC(=C(C=C2)F)F)CO
Isomeric SMILES:C1[C@H](OC(=O)N1C2=CC(=C(C=C2)F)F)CO

Technology Process of (5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one

There total 1 articles about (5S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3863-11-4
3,4-difluoroaniline

: 919081-43-9
(S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHCO₃ / acetone; H₂O / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; sodium hydrogencarbonate; In tetrahydrofuran; hexane; water; acetone;
DOI:10.1021/jm060666p

Reference yield:

: 919081-43-9
(S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

: 918543-52-9
(S)-3-(3,4-difluorophenyl)-2-oxooxazolidine-5-carboxylic acid

Guidance literature:: With sodium periodate; ruthenium trichloride; In tetrachloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1021/jm060666p

Reference yield:

: 919081-43-9
(S)-3-(3,4-difluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one

: 1066876-01-4
3-(3,4-difluoro-phenyl)-2-oxo-oxazolidine-5-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: NaIO₄ / RuCl₃*H₂O / acetonitrile; CCl₄ / 0 - 20 °C

2: oxalyl chloride / 20 °C

With sodium periodate; oxalyl dichloride; ruthenium trichloride; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm060666p