Technology Process of Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid,
1-(3,4-dimethoxyphenyl)-5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-
bis(phenylmethoxy)phenyl]-, ethyl ester
There total 9 articles about Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid,
1-(3,4-dimethoxyphenyl)-5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-
bis(phenylmethoxy)phenyl]-, ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
acetonitrile;
for 18h;
Heating;
DOI:10.1021/jo061810h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
2: sodium carbonate / dichloromethane; water / 2 h / 20 °C
3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
4: sodium hydrogencarbonate / acetonitrile / 18 h / Heating
With
oxalyl dichloride; sodium hydrogencarbonate; sodium carbonate; N,N-dimethyl-formamide; trichlorophosphate;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
3: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate / dichloromethane; water / 2 h / 20 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C
3: sodium hydrogencarbonate / acetonitrile / 18 h / Heating
With
sodium hydrogencarbonate; sodium carbonate; trichlorophosphate;
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
2: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h
