Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester

Base Information

Chemical Name:Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester
CAS No.:919082-32-9
Molecular Formula:C53H51NO10
Molecular Weight:861.989
Hs Code.:

Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid,
5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen
yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester

Synonyms:

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Chemical Property of Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester

There total 7 articles about Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-7,8,9-trimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phen yl]-1-[3-methoxy-4-(phenylmethoxy)phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 919082-25-0
1-(4-benzyloxy-3-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline

: 1034028-91-5
(Z)-ethyl 2,4-bis(benzyloxy)-5-methoxy-α-nitrocinnamate

: 919082-32-9
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7,8,9-trimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 18h; Heating;
DOI:10.1021/jo061810h

Reference yield:

: 2-(4-benzyloxy-3-methoxy-phenyl)-N-[2-(2,3,4-trimethoxy-phenyl)-ethyl]-acetamide

: 919082-32-9
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7,8,9-trimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

2: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With sodium hydrogencarbonate; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; 1: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h

Reference yield:

: 3937-16-4
2-(2,3,4-trimethoxyphenyl)ethylamine

: 919082-32-9
ethyl 1-(4-benzyloxy-3-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7,8,9-trimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dichloromethane; water / 2 h / 20 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

3: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With sodium hydrogencarbonate; sodium carbonate; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 2: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h