Glycine, N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]- 1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]-

Base Information

Chemical Name:Glycine, N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]- 1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]-
CAS No.:919110-28-4
Molecular Formula:C27H31ClN6O5S
Molecular Weight:587.099
Hs Code.:

Glycine,
N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]-
1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Glycine, N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]- 1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]- 1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]-

There total 5 articles about Glycine, N-[(5-chloro-1H-indol-2-yl)sulfonyl]-N-[2-[[[4-[1-[2-(dimethylamino)ethyl]- 1,6-dihydro-6-oxo-3-pyridazinyl]phenyl]methyl]amino]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 763053-53-8
6-chloro-2-(2-dimethylamino-ethyl)-2H-pyridazin-3-one

: 919110-25-1
N-((5-chloro-1H-indol-2-yl)-sulfonyl)-N-(2-((4-dihydroxyborylbenzyl)amino)ethyl)glycine

: 919110-28-4
((5-chloro-1H-indole-2-sulfonyl)-(2-(-(1-(2-dimethylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)amino)acetic acid

Guidance literature:: With caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.0222222h;

Reference yield:

: 249292-35-1
5-chloro-1-phenyl-sulfonylindole-2-sulfonyl chloride

: 919110-28-4
((5-chloro-1H-indole-2-sulfonyl)-(2-(-(1-(2-dimethylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

2.1: sodium hydroxide / water / 0.33 h / 80 °C

2.2: acid

3.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.02 h / 150 °C

With sodium hydroxide; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 919110-17-1
4-(4-iodobenzyl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

: 919110-28-4
((5-chloro-1H-indole-2-sulfonyl)-(2-(-(1-(2-dimethylaminoethyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzylamino)ethyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 2 h / 100 °C

1.2: 0.5 h

2.1: triethylamine / water; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3.1: sodium hydroxide / water / 0.33 h / 80 °C

3.2: acid

4.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.02 h / 150 °C

With sodium hydroxide; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;