4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one

Base Information

Chemical Name:4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one
CAS No.:175437-65-7
Molecular Formula:C₁₆H₁₈N₂O₄S
Molecular Weight:334.396
Hs Code.:
Mol file:175437-65-7.mol

Synonyms:4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one

Suppliers and Price of 4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one

Chemical Property:

Vapor Pressure:2.07E-11mmHg at 25°C
Boiling Point:514.5°Cat760mmHg
Flash Point:264.9°C
PSA：124.47000
Density:1.34g/cm³
LogP:3.91150

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one

There total 4 articles about 4-(3,5-dimethylphenyl)sulfanyl-6-(3-hydroxypropyl)-3-nitro-1H-pyridin- 2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 175437-64-6
Acetic acid 3-[4-(3,5-dimethyl-phenylsulfanyl)-5-nitro-6-oxo-1,6-dihydro-pyridin-2-yl]-propyl ester

: 175437-65-7
4-(3,5-Dimethyl-phenylsulfanyl)-6-(3-hydroxy-propyl)-3-nitro-1H-pyridin-2-one

Guidance literature:: With methanol; ammonia;
DOI:10.1016/0960-894X(95)00584-G

Reference yield:

: 175437-60-2
4-Hydroxy-6-(3-hydroxy-propyl)-1H-pyridin-2-one

: 175437-65-7
4-(3,5-Dimethyl-phenylsulfanyl)-6-(3-hydroxy-propyl)-3-nitro-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / HNO₃ / ethyl acetate / 1 h / 100 °C

2: 76 percent / POCl₃, Et₃(PCH₂)NCl / acetonitrile / 1.) 40 deg C, 30 min, 2.) reflux, 40 min

3: 73 percent / Et₃N / ethanol / Ambient temperature

4: 93 percent / NH₃/MeOH

With methanol; N-benzyl-N,N,N-triethylammonium chloride; ammonia; nitric acid; triethylamine; trichlorophosphate; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/0960-894X(95)00584-G

Reference yield:

: 175437-63-5
Acetic acid 3-(4-chloro-5-nitro-6-oxo-1,6-dihydro-pyridin-2-yl)-propyl ester

: 175437-65-7
4-(3,5-Dimethyl-phenylsulfanyl)-6-(3-hydroxy-propyl)-3-nitro-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / Et₃N / ethanol / Ambient temperature

2: 93 percent / NH₃/MeOH

With methanol; ammonia; triethylamine; In ethanol;
DOI:10.1016/0960-894X(95)00584-G