1-Fluoro-4-[3-(piperazin-1-yl)propoxy]benzene

Base Information

• Chemical Name: 1-Fluoro-4-[3-(piperazin-1-yl)propoxy]benzene
• CAS No.: 91940-44-2
• Molecular Formula: C13H19FN2O
• Molecular Weight: 238.305
• Hs Code.: 2933599590
• Mol file: 91940-44-2.mol

Synonyms:Benzenesulfonic acid,4-(3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-,sodium salt;p-(3-(p-Chlorophenyl)-2-pyrazolin-1-yl)benzenesulfonic acid sodium salt;Benzenesulfonic acid,p-(3-(p-chlorophenyl)-2-pyrazolin-1-yl)-,sodium salt;Compound 47-3;1-(3-(4-fluorophenoxy)propyl)piperazine;4-[3-(4-fluorophenoxy)propyl]piperazine;1-(4'-Sulfophenyl)-3-(4''-chlorphenyl)pyrazolin sodium salt;1-[3-(p-fluorophenoxy) propyl]-piperazine;Belophor;

Chemical Property of 1-Fluoro-4-[3-(piperazin-1-yl)propoxy]benzene

Chemical Property:

• PSA: 24.50000
• LogP: 1.76650

Purity/Quality:

98% ^*data from raw suppliers

1-[3-(4-Fluorophenoxy)propyl]piperazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Fluoro-4-[3-(piperazin-1-yl)propoxy]benzene

There total 3 articles about 1-Fluoro-4-[3-(piperazin-1-yl)propoxy]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-bromopropoxy)-4-fluorobenzene (1129-78-8) → 1-(3-(4-fluorophenoxy)propyl)piperazine (91940-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / Heating

2: 45 percent HBr

With hydrogen bromide; potassium carbonate; In acetonitrile;

DOI:10.1021/jm981098j

Reference yield:

piperazine (110-85-0) + 1-(3-bromopropoxy)-4-fluorobenzene (1129-78-8) → 1-(3-(4-fluorophenoxy)propyl)piperazine (91940-44-2)

Guidance literature:

With potassium carbonate; In ethanol; at 70 ℃; for 8h;

DOI:10.1016/j.ejmech.2009.05.018

Reference yield:

4-[3-(4-fluoro-phenoxy)-propyl]-piperazine-1-carboxylic acid ethyl ester → 1-(3-(4-fluorophenoxy)propyl)piperazine (91940-44-2)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jm981098j

upstream raw materials:

1-(3-bromopropoxy)-4-fluorobenzene

piperazine

Downstream raw materials:

1-[(3-cyano-4-methyl-3-phenyl)pentyl]-4-[3-(4-fluorophenoxy)propyl]piperazine

4-[3-(p-fluorophenoxy) propyl]-N-methyl-1-piperazinecarboxamide

p-nitrophenyl-4-[3-(p-fluorophenoxy) propyl]-1-piperazine-carboxylate

4-[3-(p-fluorophenoxy) propyl]-1-piperazine carboxamide