1H-Indole-1,2-dicarboxylic acid, 5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo- 7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester

Base Information

Chemical Name:1H-Indole-1,2-dicarboxylic acid, 5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo- 7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester
CAS No.:919535-10-7
Molecular Formula:C30H34ClIN2O7
Molecular Weight:696.967
Hs Code.:

1H-Indole-1,2-dicarboxylic acid,
5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-
7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester

Synonyms:

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Chemical Property of 1H-Indole-1,2-dicarboxylic acid, 5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo- 7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indole-1,2-dicarboxylic acid, 5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo- 7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester

There total 17 articles about 1H-Indole-1,2-dicarboxylic acid, 5-[(3-chloro-2-propen-1-yl)[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo- 7-(phenylmethoxy)-, 1-(1,1-dimethylethyl) 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 919535-06-1
1-(1,1-dimethylethyl)-2-methyl 5-[[(1,1-dimethylethoxy)-carbonyl]amino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate

: 10061-02-6
(E)-1,3-dichloro-prop-1-ene

: 919535-10-7
1-(1,1-dimethylethyl)-2-methyl 5-[(3-chloro-2-propenyl)-(1,1-dimethylethoxy)carbonylamino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 2h;
DOI:10.1021/ja064228j

Reference yield:

: 539856-42-3
methyl 7-(benzyloxy)-5-nitro-1H-indole-2-carboxylate

: 919535-10-7
1-(1,1-dimethylethyl)-2-methyl 5-[(3-chloro-2-propenyl)-(1,1-dimethylethoxy)carbonylamino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / DMAP / tetrahydrofuran / 1 h / 25 °C

2: 98 percent / Zn; NH₄Cl / acetone; H₂O / 0.5 h / 25 °C

3: 227 mg / tetrahydrofuran / 10 h / 25 °C

4: 91 percent / N-iodosuccinimide; AcOH / toluene / 8 h / 25 °C

5: 86 percent / NaH / dimethylformamide / 2 h / 0 °C

With dmap; N-iodo-succinimide; sodium hydride; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja064228j

Reference yield:

: 539856-49-0
1-(1,1-dimethylethyl)-2-methyl-5-nitro-6-(phenylmethoxy)-indole-1,2-dicarboxylate

: 919535-10-7
1-(1,1-dimethylethyl)-2-methyl 5-[(3-chloro-2-propenyl)-(1,1-dimethylethoxy)carbonylamino]-4-iodo-7-(phenylmethoxy)indole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Zn; NH₄Cl / acetone; H₂O / 0.5 h / 25 °C

2: 227 mg / tetrahydrofuran / 10 h / 25 °C

3: 91 percent / N-iodosuccinimide; AcOH / toluene / 8 h / 25 °C

4: 86 percent / NaH / dimethylformamide / 2 h / 0 °C

With N-iodo-succinimide; sodium hydride; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/ja064228j