4-Piperidinecarboxamide, N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-( 1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-

Base Information

Chemical Name:4-Piperidinecarboxamide, N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-( 1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-
CAS No.:919536-23-5
Molecular Formula:C27H29ClN6O6S2
Molecular Weight:633.149
Hs Code.:

4-Piperidinecarboxamide,
N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-(
1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-

Synonyms:

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Piperidinecarboxamide, N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-( 1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-

Chemical Property:

PSA：169.23000
Density:1.52±0.1 g/cm3(Predicted)
LogP:4.94490

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Piperidinecarboxamide, N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-( 1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-

There total 5 articles about 4-Piperidinecarboxamide, N-[2-[[[3-chloro-1-(phenylsulfonyl)-1H-indol-6-yl]sulfonyl]amino]ethyl]-1-( 1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 919110-32-0
1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl chloride

: 919536-22-4
1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-piperidine-4-carboxylic acid (2-aminoethyl)-amide hydrochloride

: 919536-23-5
1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-piperidine-4-carboxylic acid (2-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonylamino)-ethyl)-amide

Guidance literature:: 1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonyl chloride; 1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-piperidine-4-carboxylic acid (2-aminoethyl)-amide hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

With potassium hydrogensulfate; In dichloromethane; water; pH=4;

Reference yield:

: 498-94-2
isonipecotic acid

: 919536-23-5
1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-piperidine-4-carboxylic acid (2-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonylamino)-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol; water / 15 h / 180 °C

1.2: 1.5 h / 70 °C

1.3: pH 5

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

2.2: 0 °C / pH 6

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 1.5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.2: pH 4

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10071-38-2
6-Chloro-2-methyl-2H-pyridazin-3-one

: 919536-23-5
1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-piperidine-4-carboxylic acid (2-(1-benzenesulfonyl-3-chloro-1H-indole-6-sulfonylamino)-ethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / ethanol; water / 15 h / 180 °C

1.2: 1.5 h / 70 °C

1.3: pH 5

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

2.2: 0 °C / pH 6

3.1: hydrogenchloride / 1,4-dioxane; ethanol / 1.5 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4.2: pH 4

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;